Detailed information of TA system TA197236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1971459..1971929
• Replicon: chromosome
• Accession: NZ_CP071994
• Organism: Staphylococcus epidermidis strain AZ22

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: J4Z28_RS09400
• Protein ID: WP_001829569.1
• Coordinates: 1971741..1971929 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: J4Z28_RS09395
• Protein ID: WP_002438963.1
• Coordinates: 1971459..1971716 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4Z28_RS09355 (J4Z28_001868)	1966827..1967543	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
J4Z28_RS09360 (J4Z28_001869)	1967704..1968126	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
J4Z28_RS09365 (J4Z28_001870)	1968310..1968447	-	138	WP_162158130.1	hypothetical protein	-
J4Z28_RS09370	1968477..1968664	-	188	Protein_1815	hypothetical protein	-
J4Z28_RS09375 (J4Z28_001871)	1969050..1969550	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
J4Z28_RS09380 (J4Z28_001872)	1969818..1970405	-	588	WP_001829615.1	histidine phosphatase family protein	-
J4Z28_RS09385 (J4Z28_001873)	1970619..1970855	+	237	WP_002457224.1	hypothetical protein	-
J4Z28_RS09390 (J4Z28_001874)	1970847..1971050	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
J4Z28_RS09395	1971459..1971716	+	258	WP_002438963.1	hypothetical protein	Antitoxin
J4Z28_RS09400 (J4Z28_001875)	1971741..1971929	+	189	WP_001829569.1	hypothetical protein	Toxin
J4Z28_RS09405 (J4Z28_001876)	1972119..1972673	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
J4Z28_RS09410 (J4Z28_001877)	1972733..1972966	-	234	WP_001829664.1	hypothetical protein	-
J4Z28_RS09415 (J4Z28_001878)	1973247..1973993	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
J4Z28_RS09420 (J4Z28_001879)	1974092..1974376	+	285	WP_001829635.1	hypothetical protein	-
J4Z28_RS09425 (J4Z28_001880)	1974400..1974624	+	225	WP_001829613.1	hypothetical protein	-
J4Z28_RS09430 (J4Z28_001881)	1975248..1975448	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1968310..1968465	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T197236 WP_001829569.1 NZ_CP071994:1971741-1971929 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T197236 NZ_CP095843:c1104419-1104168 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT197236 WP_002438963.1 NZ_CP071994:1971459-1971716 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT197236 NZ_CP095843:c1104171-1103917 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3