Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1949796..1950584 Replicon chromosome
Accession NZ_CP071994
Organism Staphylococcus epidermidis strain AZ22

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J4Z28_RS09250 Protein ID WP_233944806.1
Coordinates 1950123..1950584 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag J4Z28_RS09245 Protein ID WP_002498323.1
Coordinates 1949796..1950110 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z28_RS09190 (J4Z28_001835) 1944981..1945757 - 777 WP_002468156.1 ATP-binding protein -
J4Z28_RS09195 (J4Z28_001836) 1945758..1946243 - 486 WP_002498316.1 siphovirus Gp157 family protein -
J4Z28_RS09200 (J4Z28_001837) 1946227..1946490 - 264 WP_002468154.1 hypothetical protein -
J4Z28_RS09205 (J4Z28_001838) 1946556..1946738 - 183 WP_002498317.1 hypothetical protein -
J4Z28_RS09210 (J4Z28_001839) 1946735..1946950 - 216 WP_002468180.1 hypothetical protein -
J4Z28_RS09215 (J4Z28_001840) 1947058..1947261 + 204 WP_002468183.1 hypothetical protein -
J4Z28_RS09220 (J4Z28_001841) 1947369..1947857 - 489 WP_002498318.1 ORF6C domain-containing protein -
J4Z28_RS09225 (J4Z28_001842) 1947916..1948296 + 381 WP_002498319.1 DUF2513 domain-containing protein -
J4Z28_RS09230 (J4Z28_001843) 1948288..1948464 - 177 WP_002498320.1 hypothetical protein -
J4Z28_RS09235 (J4Z28_001844) 1948475..1949392 - 918 WP_080352717.1 hypothetical protein -
J4Z28_RS09240 (J4Z28_001845) 1949407..1949643 - 237 WP_002498322.1 helix-turn-helix transcriptional regulator -
J4Z28_RS09245 (J4Z28_001846) 1949796..1950110 + 315 WP_002498323.1 helix-turn-helix transcriptional regulator Antitoxin
J4Z28_RS09250 (J4Z28_001847) 1950123..1950584 + 462 WP_233944806.1 ImmA/IrrE family metallo-endopeptidase Toxin
J4Z28_RS09255 (J4Z28_001848) 1950753..1950920 + 168 WP_002498324.1 hypothetical protein -
J4Z28_RS09260 (J4Z28_001849) 1950942..1952081 + 1140 WP_002498325.1 CapA family protein -
J4Z28_RS09265 (J4Z28_001850) 1952297..1953346 + 1050 WP_002498326.1 tyrosine-type recombinase/integrase -
J4Z28_RS09270 (J4Z28_001851) 1953414..1954811 - 1398 WP_002498327.1 Fe-S cluster assembly protein SufB -
J4Z28_RS09275 (J4Z28_001852) 1955017..1955481 - 465 WP_001831954.1 SUF system NifU family Fe-S cluster assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1912582..1954811 42229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(33-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17895.51 Da        Isoelectric Point: 5.0503

>T197235 WP_233944806.1 NZ_CP071994:1950123-1950584 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYALTTRCGDYVIAFEPLRVFEYKEI

Download         Length: 462 bp

>T197235 NZ_CP095843:c1104171-1103917 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12044.60 Da        Isoelectric Point: 5.7723

>AT197235 WP_002498323.1 NZ_CP071994:1949796-1950110 [Staphylococcus epidermidis]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIEDVEEQPQHRAAHL
DGDLTDEEWQEILDYAEYIRSKRK

Download         Length: 315 bp

>AT197235 NZ_CP095843:c1104419-1104168 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References