Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 810037..810566 Replicon chromosome
Accession NZ_CP071994
Organism Staphylococcus epidermidis strain AZ22

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag J4Z28_RS03750 Protein ID WP_001829891.1
Coordinates 810204..810566 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag J4Z28_RS03745 Protein ID WP_001829931.1
Coordinates 810037..810207 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z28_RS03720 (J4Z28_000748) 805861..806340 + 480 WP_002457111.1 PH domain-containing protein -
J4Z28_RS03725 (J4Z28_000749) 806333..807838 + 1506 WP_233944882.1 PH domain-containing protein -
J4Z28_RS03730 (J4Z28_000750) 807825..808334 + 510 WP_002457109.1 PH domain-containing protein -
J4Z28_RS03735 (J4Z28_000751) 808382..808735 + 354 WP_029376481.1 holo-ACP synthase -
J4Z28_RS03740 (J4Z28_000752) 808802..809950 + 1149 WP_002457107.1 alanine racemase -
J4Z28_RS03745 (J4Z28_000753) 810037..810207 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
J4Z28_RS03750 (J4Z28_000754) 810204..810566 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J4Z28_RS03755 (J4Z28_000755) 810911..811912 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
J4Z28_RS03760 (J4Z28_000756) 812012..812338 + 327 WP_001829952.1 anti-sigma factor antagonist -
J4Z28_RS03765 (J4Z28_000757) 812340..812819 + 480 WP_001829903.1 anti-sigma B factor RsbW -
J4Z28_RS03770 (J4Z28_000758) 812794..813564 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T197233 WP_001829891.1 NZ_CP071994:810204-810566 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T197233 NZ_CP095842:c1242123-1241377 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT197233 WP_001829931.1 NZ_CP071994:810037-810207 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT197233 NZ_CP095842:c1241376-1241206 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References