Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 798852..799361 Replicon chromosome
Accession NZ_CP071994
Organism Staphylococcus epidermidis strain AZ22

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag J4Z28_RS03690 Protein ID WP_001829980.1
Coordinates 799152..799361 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag J4Z28_RS03685 Protein ID WP_001829893.1
Coordinates 798852..799145 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z28_RS03660 (J4Z28_000736) 793860..794648 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
J4Z28_RS03665 (J4Z28_000737) 794654..795292 + 639 WP_002505076.1 thiamine phosphate synthase -
J4Z28_RS03670 (J4Z28_000738) 795381..796253 + 873 WP_002458703.1 membrane protein insertase YidC -
J4Z28_RS03675 (J4Z28_000739) 796359..797012 - 654 WP_001829983.1 HD domain-containing protein -
J4Z28_RS03680 (J4Z28_000740) 797194..798678 - 1485 WP_002457116.1 cardiolipin synthase -
J4Z28_RS03685 (J4Z28_000741) 798852..799145 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
J4Z28_RS03690 (J4Z28_000742) 799152..799361 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
J4Z28_RS03695 (J4Z28_000743) 799504..799641 + 138 WP_001829949.1 Lmo0850 family protein -
J4Z28_RS03700 (J4Z28_000744) 799740..800951 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
J4Z28_RS03705 (J4Z28_000745) 801342..802415 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
J4Z28_RS03710 (J4Z28_000746) 802427..803782 + 1356 WP_002470674.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T197232 WP_001829980.1 NZ_CP071994:799152-799361 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T197232 NZ_CP095842:490252-490602 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT197232 WP_001829893.1 NZ_CP071994:798852-799145 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT197232 NZ_CP095842:489965-490246 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References