Detailed information of TA system TA197231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2033446..2033916
• Replicon: chromosome
• Accession: NZ_CP071992
• Organism: Staphylococcus epidermidis strain CBPA-ST-11003

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A939NNQ7
• Locus tag: J4Z27_RS09610
• Protein ID: WP_002445998.1
• Coordinates: 2033728..2033916 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A829M688
• Locus tag: J4Z27_RS09605
• Protein ID: WP_002445999.1
• Coordinates: 2033446..2033703 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4Z27_RS09570 (J4Z27_001904)	2028714..2029256	-	543	WP_002446007.1	nitroreductase	-
J4Z27_RS09575 (J4Z27_001905)	2029337..2030053	-	717	WP_002446006.1	type I 3-dehydroquinate dehydratase	-
J4Z27_RS09580 (J4Z27_001906)	2030214..2030636	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
J4Z27_RS09585 (J4Z27_001907)	2031042..2031542	+	501	WP_002446003.1	GNAT family N-acetyltransferase	-
J4Z27_RS09590 (J4Z27_001908)	2031813..2032400	-	588	WP_233931968.1	histidine phosphatase family protein	-
J4Z27_RS09595 (J4Z27_001909)	2032614..2032850	+	237	WP_002446001.1	hypothetical protein	-
J4Z27_RS09600 (J4Z27_001910)	2032842..2033045	-	204	WP_002446000.1	sterile alpha motif-like domain-containing protein	-
J4Z27_RS09605	2033446..2033703	+	258	WP_002445999.1	hypothetical protein	Antitoxin
J4Z27_RS09610 (J4Z27_001911)	2033728..2033916	+	189	WP_002445998.1	hypothetical protein	Toxin
J4Z27_RS09615 (J4Z27_001912)	2034106..2034660	+	555	WP_002445997.1	lipoprotein N-acylation protein LnsA	-
J4Z27_RS09620 (J4Z27_001913)	2034719..2034952	-	234	WP_002445996.1	hypothetical protein	-
J4Z27_RS09625 (J4Z27_001914)	2035166..2035912	+	747	WP_002445995.1	poly-gamma-glutamate hydrolase family protein	-
J4Z27_RS09630 (J4Z27_001915)	2036011..2036295	+	285	WP_001829635.1	hypothetical protein	-
J4Z27_RS09635 (J4Z27_001916)	2036320..2036544	+	225	WP_002495809.1	hypothetical protein	-
J4Z27_RS09640 (J4Z27_001917)	2037165..2037365	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2030211..2059917	29706

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7257.95 Da
• Isoelectric Point: 9.8369

>T197231 WP_002445998.1 NZ_CP071992:2033728-2033916 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T197231 NZ_CP095841:911167-912486 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAATCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GTGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACAGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCAGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATAATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAGCTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAAAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT197231 WP_002445999.1 NZ_CP071992:2033446-2033703 [Staphylococcus epidermidis]
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT197231 NZ_CP095841:910913-911167 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCGCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAGACCCTGT
TCAAAATCCTCGCAGCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGACAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A829M688