197229

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 868814..869343 Replicon chromosome
Accession NZ_CP071992
Organism Staphylococcus epidermidis strain CBPA-ST-11003

Toxin (Protein)


Gene name mazF Uniprot ID A0A939SRT1
Locus tag J4Z27_RS04025 Protein ID WP_002447757.1
Coordinates 868981..869343 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag J4Z27_RS04020 Protein ID WP_001829931.1
Coordinates 868814..868984 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z27_RS03995 (J4Z27_000796) 864638..865117 + 480 WP_002447762.1 PH domain-containing protein -
J4Z27_RS04000 (J4Z27_000797) 865110..866615 + 1506 WP_002447761.1 PH domain-containing protein -
J4Z27_RS04005 (J4Z27_000798) 866602..867120 + 519 WP_002447760.1 PH domain-containing protein -
J4Z27_RS04010 (J4Z27_000799) 867159..867512 + 354 WP_002447759.1 holo-ACP synthase -
J4Z27_RS04015 (J4Z27_000800) 867579..868727 + 1149 WP_002458690.1 alanine racemase -
J4Z27_RS04020 (J4Z27_000801) 868814..868984 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
J4Z27_RS04025 (J4Z27_000802) 868981..869343 + 363 WP_002447757.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J4Z27_RS04030 (J4Z27_000803) 869688..870689 + 1002 WP_002447756.1 PP2C family protein-serine/threonine phosphatase -
J4Z27_RS04035 (J4Z27_000804) 870789..871115 + 327 WP_001829952.1 anti-sigma factor antagonist -
J4Z27_RS04040 (J4Z27_000805) 871117..871596 + 480 WP_002447755.1 anti-sigma B factor RsbW -
J4Z27_RS04045 (J4Z27_000806) 871571..872341 + 771 WP_233932073.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13483.62 Da        Isoelectric Point: 9.9522

>T197229 WP_002447757.1 NZ_CP071992:868981-869343 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T197229 NZ_CP095790:69052-69204 [Escherichia fergusonii]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT197229 WP_001829931.1 NZ_CP071992:868814-868984 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT197229 NZ_CP095790:c69002-68940 [Escherichia fergusonii]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References