Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 857627..858136 Replicon chromosome
Accession NZ_CP071992
Organism Staphylococcus epidermidis strain CBPA-ST-11003

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag J4Z27_RS03965 Protein ID WP_002447767.1
Coordinates 857927..858136 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag J4Z27_RS03960 Protein ID WP_002458700.1
Coordinates 857627..857920 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z27_RS03935 (J4Z27_000784) 852634..853422 + 789 WP_002486939.1 hydroxyethylthiazole kinase -
J4Z27_RS03940 (J4Z27_000785) 853428..854066 + 639 WP_002458704.1 thiamine phosphate synthase -
J4Z27_RS03945 (J4Z27_000786) 854155..855027 + 873 WP_002458703.1 membrane protein insertase YidC -
J4Z27_RS03950 (J4Z27_000787) 855134..855787 - 654 WP_002495677.1 HD domain-containing protein -
J4Z27_RS03955 (J4Z27_000788) 855969..857453 - 1485 WP_203422592.1 cardiolipin synthase -
J4Z27_RS03960 (J4Z27_000789) 857627..857920 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
J4Z27_RS03965 (J4Z27_000790) 857927..858136 + 210 WP_002447767.1 cation transporter Toxin
J4Z27_RS03970 (J4Z27_000791) 858279..858416 + 138 WP_001829949.1 Lmo0850 family protein -
J4Z27_RS03975 (J4Z27_000792) 858515..859726 - 1212 WP_002447766.1 FtsW/RodA/SpoVE family cell cycle protein -
J4Z27_RS03980 (J4Z27_000793) 860117..861190 + 1074 WP_002458698.1 D-alanine--D-alanine ligase -
J4Z27_RS03985 (J4Z27_000794) 861202..862557 + 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T197228 WP_002447767.1 NZ_CP071992:857927-858136 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T197228 NZ_CP095789:8872-9288 [Escherichia fergusonii]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT197228 WP_002458700.1 NZ_CP071992:857627-857920 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT197228 NZ_CP095789:8645-8875 [Escherichia fergusonii]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References