Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 990887..991689 Replicon chromosome
Accession NZ_CP071988
Organism Staphylococcus epidermidis strain CBPA-ST-10002 isolate HPB10235

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag J4Z26_RS04765 Protein ID WP_002468490.1
Coordinates 991510..991689 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag J4Z26_RS04760 Protein ID WP_002456349.1
Coordinates 990887..991486 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z26_RS04735 (J4Z26_000944) 986098..987555 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
J4Z26_RS04740 (J4Z26_000945) 987548..988270 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
J4Z26_RS04745 (J4Z26_000946) 988785..988922 + 138 WP_064783702.1 hypothetical protein -
J4Z26_RS04750 (J4Z26_000947) 989132..990262 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
J4Z26_RS04755 (J4Z26_000948) 990259..990729 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
J4Z26_RS04760 (J4Z26_000949) 990887..991486 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
J4Z26_RS04765 (J4Z26_000950) 991510..991689 + 180 WP_002468490.1 SAS053 family protein Toxin
J4Z26_RS04770 (J4Z26_000951) 991845..992249 + 405 WP_001829818.1 hypothetical protein -
J4Z26_RS04775 (J4Z26_000952) 992434..993819 + 1386 WP_001829862.1 class II fumarate hydratase -
J4Z26_RS04780 (J4Z26_000953) 994180..995004 - 825 WP_001829804.1 RluA family pseudouridine synthase -
J4Z26_RS04785 (J4Z26_000954) 995163..996296 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T197226 WP_002468490.1 NZ_CP071988:991510-991689 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T197226 NZ_CP095788:c64599-64219 [Escherichia fergusonii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCAGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT197226 WP_002456349.1 NZ_CP071988:990887-991486 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT197226 NZ_CP095788:c64820-64599 [Escherichia fergusonii]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References