Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 831090..831599 Replicon chromosome
Accession NZ_CP071988
Organism Staphylococcus epidermidis strain CBPA-ST-10002 isolate HPB10235

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag J4Z26_RS03855 Protein ID WP_001829980.1
Coordinates 831390..831599 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag J4Z26_RS03850 Protein ID WP_001829893.1
Coordinates 831090..831383 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Z26_RS03825 (J4Z26_000765) 826098..826886 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
J4Z26_RS03830 (J4Z26_000766) 826892..827530 + 639 WP_002505076.1 thiamine phosphate synthase -
J4Z26_RS03835 (J4Z26_000767) 827619..828491 + 873 WP_002458703.1 membrane protein insertase YidC -
J4Z26_RS03840 (J4Z26_000768) 828597..829250 - 654 WP_001829983.1 HD domain-containing protein -
J4Z26_RS03845 (J4Z26_000769) 829432..830916 - 1485 WP_002457116.1 cardiolipin synthase -
J4Z26_RS03850 (J4Z26_000770) 831090..831383 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
J4Z26_RS03855 (J4Z26_000771) 831390..831599 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
J4Z26_RS03860 (J4Z26_000772) 831742..831879 + 138 WP_001829949.1 Lmo0850 family protein -
J4Z26_RS03865 (J4Z26_000773) 831979..833190 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
J4Z26_RS03870 (J4Z26_000774) 833581..834654 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
J4Z26_RS03875 (J4Z26_000775) 834666..836021 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T197224 WP_001829980.1 NZ_CP071988:831390-831599 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T197224 NZ_CP095786:3690073-3690225 [Escherichia fergusonii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT197224 WP_001829893.1 NZ_CP071988:831090-831383 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT197224 NZ_CP095786:c3690031-3689979 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References