197223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 909467..909989 Replicon chromosome
Accession NZ_CP071987
Organism Helicobacter pylori strain MT5136

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5D23_RS04260 Protein ID WP_209613552.1
Coordinates 909467..909688 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5D23_RS04265 Protein ID WP_209613553.1
Coordinates 909702..909989 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5D23_RS04225 (J5D23_04225) 904609..905376 - 768 WP_000242348.1 ABC transporter ATP-binding protein -
J5D23_RS04230 (J5D23_04230) 905376..906356 - 981 WP_000921470.1 iron ABC transporter permease -
J5D23_RS04235 (J5D23_04235) 906349..907206 - 858 WP_209613551.1 SDR family oxidoreductase -
J5D23_RS04240 (J5D23_04240) 907346..907870 + 525 WP_001135603.1 acyl-CoA thioesterase -
J5D23_RS04245 (J5D23_04245) 907991..908248 - 258 WP_249936478.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
J5D23_RS04250 (J5D23_04250) 908257..908538 - 282 WP_001958503.1 hypothetical protein -
J5D23_RS04255 (J5D23_04255) 909117..909368 - 252 WP_156569247.1 hypothetical protein -
J5D23_RS04260 (J5D23_04260) 909467..909688 - 222 WP_209613552.1 type II toxin-antitoxin system YafQ family toxin Toxin
J5D23_RS04265 (J5D23_04265) 909702..909989 - 288 WP_209613553.1 type II toxin-antitoxin system antitoxin Antitoxin
J5D23_RS04270 (J5D23_04270) 910902..913145 - 2244 WP_209613554.1 outer membrane beta-barrel protein -
J5D23_RS07900 913612..914130 + 519 WP_249936504.1 hypothetical protein -
J5D23_RS07905 914163..914255 - 93 Protein_841 hypothetical protein -
J5D23_RS07910 914222..914336 - 115 Protein_842 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-72)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8453.16 Da        Isoelectric Point: 9.5857

>T197223 WP_209613552.1 NZ_CP071987:c909688-909467 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYEVVGNLATEQPLAPKYRDHPLKGALKDFRECHLKPDLLLVCQIKK

Download         Length: 222 bp

>T197223 NZ_CP095786:c3385456-3385304 [Escherichia fergusonii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11390.23 Da        Isoelectric Point: 10.1260

>AT197223 WP_209613553.1 NZ_CP071987:c909989-909702 [Helicobacter pylori]
MPNTTNKDYTKYSEKQLFNFLNSIKTKQKIALEKLKEIQAQKQRIKKVLQFKALYLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Download         Length: 288 bp

>AT197223 NZ_CP095786:3385505-3385562 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References