Detailed information of TA system TA197222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 909117..909688
• Replicon: chromosome
• Accession: NZ_CP071987
• Organism: Helicobacter pylori strain MT5136

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5D23_RS04260
• Protein ID: WP_209613552.1
• Coordinates: 909467..909688 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J5D23_RS04255
• Protein ID: WP_156569247.1
• Coordinates: 909117..909368 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5D23_RS04225 (J5D23_04225)	904609..905376	-	768	WP_000242348.1	ABC transporter ATP-binding protein	-
J5D23_RS04230 (J5D23_04230)	905376..906356	-	981	WP_000921470.1	iron ABC transporter permease	-
J5D23_RS04235 (J5D23_04235)	906349..907206	-	858	WP_209613551.1	SDR family oxidoreductase	-
J5D23_RS04240 (J5D23_04240)	907346..907870	+	525	WP_001135603.1	acyl-CoA thioesterase	-
J5D23_RS04245 (J5D23_04245)	907991..908248	-	258	WP_249936478.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
J5D23_RS04250 (J5D23_04250)	908257..908538	-	282	WP_001958503.1	hypothetical protein	-
J5D23_RS04255 (J5D23_04255)	909117..909368	-	252	WP_156569247.1	hypothetical protein	Antitoxin
J5D23_RS04260 (J5D23_04260)	909467..909688	-	222	WP_209613552.1	type II toxin-antitoxin system YafQ family toxin	Toxin
J5D23_RS04265 (J5D23_04265)	909702..909989	-	288	WP_209613553.1	type II toxin-antitoxin system antitoxin	-
J5D23_RS04270 (J5D23_04270)	910902..913145	-	2244	WP_209613554.1	outer membrane beta-barrel protein	-
J5D23_RS07900	913612..914130	+	519	WP_249936504.1	hypothetical protein	-
J5D23_RS07905	914163..914255	-	93	Protein_841	hypothetical protein	-
J5D23_RS07910	914222..914336	-	115	Protein_842	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8453.16 Da
• Isoelectric Point: 9.5857

>T197222 WP_209613552.1 NZ_CP071987:c909688-909467 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYEVVGNLATEQPLAPKYRDHPLKGALKDFRECHLKPDLLLVCQIKK

Nucleotide

• Length: 222 bp

>T197222 NZ_CP095786:c3300535-3300071 [Escherichia fergusonii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9592.64 Da
• Isoelectric Point: 4.4620

>AT197222 WP_156569247.1 NZ_CP071987:c909368-909117 [Helicobacter pylori]
MPNTTNKDYTKYSQRQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAMKEALNGENLETIEDFSAWANEIKKEVN
AEN

Nucleotide

• Length: 252 bp

>AT197222 NZ_CP095786:c3300870-3300535 [Escherichia fergusonii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACAATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGGCTGGACAGCATTCATTACGAAATTCTGCCTGGAGGGCAAGTATTTA
TGTGCCGATTGGGAGATGAACAGGAGGATCCTACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA