Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 705843..706414 Replicon chromosome
Accession NZ_CP071986
Organism Helicobacter pylori strain MT5124

Toxin (Protein)


Gene name relE Uniprot ID I9SMZ2
Locus tag J5D25_RS03305 Protein ID WP_001881262.1
Coordinates 705843..706115 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5D25_RS03310 Protein ID WP_156569247.1
Coordinates 706163..706414 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5D25_RS03280 (J5D25_03280) 701341..701986 - 646 Protein_638 helicase DnaB modulator -
J5D25_RS03295 (J5D25_03295) 702610..704841 + 2232 WP_209554234.1 outer membrane beta-barrel protein -
J5D25_RS03300 (J5D25_03300) 705539..705829 + 291 WP_209554235.1 type II toxin-antitoxin system antitoxin -
J5D25_RS03305 (J5D25_03305) 705843..706115 + 273 WP_001881262.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
J5D25_RS03310 (J5D25_03310) 706163..706414 + 252 WP_156569247.1 hypothetical protein Antitoxin
J5D25_RS03315 (J5D25_03315) 706996..707277 + 282 WP_209554236.1 hypothetical protein -
J5D25_RS03320 (J5D25_03320) 707286..707555 + 270 WP_209554247.1 YafQ family addiction module toxin -
J5D25_RS03325 (J5D25_03325) 707661..708185 - 525 WP_001135604.1 acyl-CoA thioesterase -
J5D25_RS03330 (J5D25_03330) 708325..709179 + 855 WP_209554249.1 SDR family oxidoreductase -
J5D25_RS03335 (J5D25_03335) 709172..710152 + 981 WP_000921461.1 iron ABC transporter permease -
J5D25_RS03340 (J5D25_03340) 710152..710919 + 768 WP_209554250.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10498.45 Da        Isoelectric Point: 9.7463

>T197221 WP_001881262.1 NZ_CP071986:705843-706115 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
LRLGSHSELF

Download         Length: 273 bp

>T197221 NZ_CP095786:c2463499-2463392 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9592.64 Da        Isoelectric Point: 4.4620

>AT197221 WP_156569247.1 NZ_CP071986:706163-706414 [Helicobacter pylori]
MPNTTNKDYTKYSQRQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAMKEALNGENLETIEDFSAWANEIKKEVN
AEN

Download         Length: 252 bp

>AT197221 NZ_CP095786:2463547-2463613 [Escherichia fergusonii]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6WHU7

Antitoxin

Source ID Structure

References