Detailed information of TA system TA197216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 914522..915059
• Replicon: chromosome
• Accession: NZ_CP071982
• Organism: Helicobacter pylori strain MT5135

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5D21_RS04280
• Protein ID: WP_033621501.1
• Coordinates: 914522..914758 (-)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M3P007
• Locus tag: J5D21_RS04285
• Protein ID: WP_001945270.1
• Coordinates: 914772..915059 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5D21_RS04250 (J5D21_04250)	909591..910571	-	981	WP_000921470.1	iron ABC transporter permease	-
J5D21_RS04255 (J5D21_04255)	910564..911421	-	858	WP_209611247.1	SDR family oxidoreductase	-
J5D21_RS04260 (J5D21_04260)	911561..912085	+	525	WP_001135603.1	acyl-CoA thioesterase	-
J5D21_RS04265 (J5D21_04265)	912149..913426	-	1278	WP_001274357.1	RNA-guided endonuclease TnpB family protein	-
J5D21_RS04270 (J5D21_04270)	913401..914054	-	654	WP_209611249.1	IS607 family transposase	-
J5D21_RS04275 (J5D21_04275)	914190..914441	-	252	WP_209611251.1	hypothetical protein	-
J5D21_RS04280 (J5D21_04280)	914522..914758	-	237	WP_033621501.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
J5D21_RS04285 (J5D21_04285)	914772..915059	-	288	WP_001945270.1	type II toxin-antitoxin system antitoxin	Antitoxin
J5D21_RS04290 (J5D21_04290)	916221..918461	-	2241	WP_209611253.1	outer membrane beta-barrel protein	-
J5D21_RS07760	919237..919755	+	519	WP_244965172.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-78)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9104.93 Da
• Isoelectric Point: 10.2736

>T197216 WP_033621501.1 NZ_CP071982:c914758-914522 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLAPKYRDHPLKGALKDFRECHLKPDLLLVYLKNKKTLFF

Nucleotide

• Length: 237 bp

>T197216 NZ_CP095786:1534027-1534245 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11390.24 Da
• Isoelectric Point: 10.4152

>AT197216 WP_001945270.1 NZ_CP071982:c915059-914772 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNFLNSIKAKQKRALEKLKEIQIQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Nucleotide

• Length: 288 bp

>AT197216 NZ_CP095786:1533626-1534000 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTGTCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Structures

Antitoxin

• AlphaFold DB: M3P007