Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 914190..914758 Replicon chromosome
Accession NZ_CP071982
Organism Helicobacter pylori strain MT5135

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5D21_RS04280 Protein ID WP_033621501.1
Coordinates 914522..914758 (-) Length 79 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5D21_RS04275 Protein ID WP_209611251.1
Coordinates 914190..914441 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5D21_RS04250 (J5D21_04250) 909591..910571 - 981 WP_000921470.1 iron ABC transporter permease -
J5D21_RS04255 (J5D21_04255) 910564..911421 - 858 WP_209611247.1 SDR family oxidoreductase -
J5D21_RS04260 (J5D21_04260) 911561..912085 + 525 WP_001135603.1 acyl-CoA thioesterase -
J5D21_RS04265 (J5D21_04265) 912149..913426 - 1278 WP_001274357.1 RNA-guided endonuclease TnpB family protein -
J5D21_RS04270 (J5D21_04270) 913401..914054 - 654 WP_209611249.1 IS607 family transposase -
J5D21_RS04275 (J5D21_04275) 914190..914441 - 252 WP_209611251.1 hypothetical protein Antitoxin
J5D21_RS04280 (J5D21_04280) 914522..914758 - 237 WP_033621501.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J5D21_RS04285 (J5D21_04285) 914772..915059 - 288 WP_001945270.1 type II toxin-antitoxin system antitoxin -
J5D21_RS04290 (J5D21_04290) 916221..918461 - 2241 WP_209611253.1 outer membrane beta-barrel protein -
J5D21_RS07760 919237..919755 + 519 WP_244965172.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-78)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 9104.93 Da        Isoelectric Point: 10.2736

>T197215 WP_033621501.1 NZ_CP071982:c914758-914522 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLAPKYRDHPLKGALKDFRECHLKPDLLLVYLKNKKTLFF

Download         Length: 237 bp

>T197215 NZ_CP095786:c1036438-1036187 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACTGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9587.69 Da        Isoelectric Point: 5.1183

>AT197215 WP_209611251.1 NZ_CP071982:c914441-914190 [Helicobacter pylori]
MPNTTKKDYTKYSQKQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAIRGALNGENLEVIEDFSAWTNERKKEVN
AEN

Download         Length: 252 bp

>AT197215 NZ_CP095786:c1036190-1035936 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References