Detailed information of TA system TA197214

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 911144..911756
• Replicon: chromosome
• Accession: NZ_CP071981
• Organism: Helicobacter pylori strain MT5111

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A083YF36
• Locus tag: J5D27_RS04270
• Protein ID: WP_025446048.1
• Coordinates: 911144..911410 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J5D27_RS04275
• Protein ID: WP_097707540.1
• Coordinates: 911391..911756 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5D27_RS04230 (J5D27_04230)	906352..907119	-	768	WP_000242348.1	ABC transporter ATP-binding protein	-
J5D27_RS04235 (J5D27_04235)	907119..908099	-	981	WP_000921461.1	iron ABC transporter permease	-
J5D27_RS04240 (J5D27_04240)	908092..908940	-	849	WP_209525325.1	SDR family oxidoreductase	-
J5D27_RS04245 (J5D27_04245)	909080..909604	+	525	WP_001135624.1	acyl-CoA thioesterase	-
J5D27_RS04250 (J5D27_04250)	909727..909978	-	252	WP_241894611.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
J5D27_RS04255 (J5D27_04255)	909987..910268	-	282	WP_209525327.1	hypothetical protein	-
J5D27_RS04260 (J5D27_04260)	910584..910832	+	249	WP_241894621.1	hypothetical protein	-
J5D27_RS04265 (J5D27_04265)	910845..911096	-	252	WP_021171773.1	hypothetical protein	-
J5D27_RS04270 (J5D27_04270)	911144..911410	-	267	WP_025446048.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
J5D27_RS04275 (J5D27_04275)	911391..911756	-	366	WP_097707540.1	hypothetical protein	Antitoxin
J5D27_RS04280 (J5D27_04280)	912363..914591	-	2229	WP_209525329.1	outer membrane beta-barrel protein	-
J5D27_RS04295 (J5D27_04295)	915237..915883	+	647	Protein_845	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10324.32 Da
• Isoelectric Point: 9.5330

>T197214 WP_025446048.1 NZ_CP071981:c911410-911144 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLPPPFKDHALKGIWKPYRECHIKPDILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T197214 NZ_CP095786:c1036190-1035936 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 14362.19 Da
• Isoelectric Point: 8.4463

>AT197214 WP_097707540.1 NZ_CP071981:c911756-911391 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNLMNKKEQEIEKLKRDRVYLEKKMAKELEKKDKSFKNKSEELNKILQEINKRANDCCFGHET
PNIETQQAMREADNKETDLFVEDFSSYSNERKKALGVEAQS

Nucleotide

• Length: 366 bp

>AT197214 NZ_CP095786:c1036438-1036187 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACTGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A083YF36