Detailed information of TA system TA197209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 920256..920821
• Replicon: chromosome
• Accession: NZ_CP071977
• Organism: Helicobacter pylori strain MT5105

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5D22_RS04315
• Protein ID: WP_209505308.1
• Coordinates: 920555..920821 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: T2T0P6
• Locus tag: J5D22_RS04310
• Protein ID: WP_021171773.1
• Coordinates: 920256..920507 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5D22_RS04285 (J5D22_04285)	915657..916637	-	981	WP_000921461.1	iron ABC transporter permease	-
J5D22_RS04290 (J5D22_04290)	916630..917487	-	858	WP_209505304.1	SDR family oxidoreductase	-
J5D22_RS04295 (J5D22_04295)	917627..918151	+	525	WP_001135623.1	acyl-CoA thioesterase	-
J5D22_RS04300 (J5D22_04300)	918215..919492	-	1278	WP_209505306.1	RNA-guided endonuclease TnpB family protein	-
J5D22_RS04305 (J5D22_04305)	919467..920120	-	654	WP_001042556.1	IS607-like element IS607 family transposase	-
J5D22_RS04310 (J5D22_04310)	920256..920507	-	252	WP_021171773.1	hypothetical protein	Antitoxin
J5D22_RS04315 (J5D22_04315)	920555..920821	-	267	WP_209505308.1	type II toxin-antitoxin system YafQ family toxin	Toxin
J5D22_RS04320 (J5D22_04320)	920802..921167	-	366	WP_001134153.1	hypothetical protein	-
J5D22_RS04325 (J5D22_04325)	921728..923971	-	2244	WP_209505316.1	outer membrane beta-barrel protein	-
J5D22_RS07930	924668..925305	+	638	Protein_858	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10266.28 Da
• Isoelectric Point: 9.8526

>T197209 WP_209505308.1 NZ_CP071977:c920821-920555 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLPPPFKDHALKGIWKPYRECHIKPGILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T197209 NZ_CP095777:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9589.67 Da
• Isoelectric Point: 5.1183

>AT197209 WP_021171773.1 NZ_CP071977:c920507-920256 [Helicobacter pylori]
MPNTTKKDYTKYSQKQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAIRGALNGENLETIEDFSAWTNERKKEVN
AEN

Nucleotide

• Length: 252 bp

>AT197209 NZ_CP095777:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Structures

Antitoxin

• AlphaFold DB: T2T0P6