Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 903899..904583 Replicon chromosome
Accession NZ_CP071975
Organism Helicobacter pylori strain MT5118

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4T92_RS04235 Protein ID WP_249936625.1
Coordinates 903899..904225 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4T92_RS04240 Protein ID WP_209552570.1
Coordinates 904206..904583 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4T92_RS04210 (J4T92_04210) 899422..900528 - 1107 WP_209553450.1 glycosyltransferase family 8 protein -
J4T92_RS04215 (J4T92_04215) 900602..901369 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
J4T92_RS04220 (J4T92_04220) 901369..902349 - 981 WP_000921454.1 iron ABC transporter permease -
J4T92_RS04225 (J4T92_04225) 902342..903190 - 849 WP_209552569.1 SDR family oxidoreductase -
J4T92_RS04230 (J4T92_04230) 903330..903854 + 525 WP_001135604.1 acyl-CoA thioesterase -
J4T92_RS04235 (J4T92_04235) 903899..904225 - 327 WP_249936625.1 YafQ family addiction module toxin Toxin
J4T92_RS04240 (J4T92_04240) 904206..904583 - 378 WP_209552570.1 hypothetical protein Antitoxin
J4T92_RS04245 (J4T92_04245) 905297..907423 - 2127 WP_209552572.1 outer membrane beta-barrel protein -
J4T92_RS07840 908017..908532 + 516 WP_283957805.1 hypothetical protein -
J4T92_RS07845 908565..908657 - 93 Protein_841 hypothetical protein -
J4T92_RS07850 908624..908744 - 121 Protein_842 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12564.97 Da        Isoelectric Point: 9.9298

>T197208 WP_249936625.1 NZ_CP071975:c904225-903899 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPRFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHNTLLCKSPTPLITLKLIAHQLPHF

Download         Length: 327 bp

>T197208 NZ_CP095776:c5271256-5270873 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14915.91 Da        Isoelectric Point: 9.3623

>AT197208 WP_209552570.1 NZ_CP071975:c904583-904206 [Helicobacter pylori]
MPNTTAEKDYTKYSQKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELKKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
RHEIPNIQTQQAMRDAYNKETDLFVEDFSSYSNERKKALGVEAQS

Download         Length: 378 bp

>AT197208 NZ_CP095776:c5271498-5271256 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References