Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1930384..1930982 Replicon chromosome
Accession NZ_CP071974
Organism Trueperella pecoris strain 15IMD0307

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J4179_RS10075 Protein ID WP_246462297.1
Coordinates 1930384..1930542 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4179_RS08755 Protein ID WP_129546583.1
Coordinates 1930689..1930982 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4179_RS08720 (J4179_08715) 1925459..1926361 - 903 WP_208584948.1 ABC transporter substrate-binding protein -
J4179_RS08725 (J4179_08720) 1926484..1926681 + 198 WP_208584949.1 helix-turn-helix domain-containing protein -
J4179_RS08730 (J4179_08725) 1926678..1927634 + 957 WP_208584950.1 SRPBCC family protein -
J4179_RS08735 (J4179_08730) 1927766..1928389 + 624 WP_246462295.1 alpha/beta hydrolase -
J4179_RS08740 (J4179_08735) 1928521..1928877 - 357 WP_208584951.1 iron ABC transporter -
J4179_RS08745 (J4179_08740) 1929206..1929991 - 786 WP_208584952.1 siderophore-interacting protein -
J4179_RS10075 1930384..1930542 + 159 WP_246462297.1 hypothetical protein Toxin
J4179_RS08755 (J4179_08750) 1930689..1930982 + 294 WP_129546583.1 putative addiction module antidote protein Antitoxin
J4179_RS08760 (J4179_08755) 1931092..1931508 + 417 WP_208584953.1 SRPBCC family protein -
J4179_RS08770 (J4179_08765) 1931945..1932652 - 708 WP_208584954.1 hypothetical protein -
J4179_RS08775 (J4179_08770) 1932652..1933641 - 990 WP_193326854.1 hypothetical protein -
J4179_RS08780 (J4179_08775) 1933781..1934995 - 1215 WP_197550993.1 molybdopterin molybdotransferase MoeA -
J4179_RS08785 (J4179_08780) 1935078..1935704 + 627 WP_208584955.1 5-formyltetrahydrofolate cyclo-ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-52)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5909.97 Da        Isoelectric Point: 10.5648

>T197206 WP_246462297.1 NZ_CP071974:1930384-1930542 [Trueperella pecoris]
VKIRQTDMYARWFRKLKDVQGKARTTIALQRCKIAGEVVGDVKPVGDGVFEM

Download         Length: 159 bp

>T197206 NZ_CP095776:c4788185-4787901 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10231.69 Da        Isoelectric Point: 4.5843

>AT197206 WP_129546583.1 NZ_CP071974:1930689-1930982 [Trueperella pecoris]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVSAIAREAGVGRESLYKSLSENGNPSWQTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp

>AT197206 NZ_CP095776:c4788417-4788175 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References