Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 44346..44956 Replicon chromosome
Accession NZ_CP071974
Organism Trueperella pecoris strain 15IMD0307

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4179_RS00220 Protein ID WP_193326609.1
Coordinates 44585..44956 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J4179_RS00215 Protein ID WP_197551203.1
Coordinates 44346..44588 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4179_RS00195 (J4179_00195) 39742..40296 - 555 WP_193326614.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
J4179_RS00200 (J4179_00200) 40296..41627 - 1332 WP_208585062.1 heparan-alpha-glucosaminide N-acetyltransferase domain-containing protein -
J4179_RS00205 (J4179_00205) 41784..42749 + 966 WP_193326612.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
J4179_RS00210 (J4179_00210) 42925..44196 - 1272 WP_208585063.1 dicarboxylate/amino acid:cation symporter -
J4179_RS00215 (J4179_00215) 44346..44588 + 243 WP_197551203.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J4179_RS00220 (J4179_00220) 44585..44956 + 372 WP_193326609.1 type II toxin-antitoxin system VapC family toxin Toxin
J4179_RS00225 (J4179_00225) 45003..45575 + 573 WP_193326608.1 low molecular weight protein-tyrosine-phosphatase -
J4179_RS00230 (J4179_00230) 45602..46390 - 789 WP_193326607.1 hypothetical protein -
J4179_RS00235 (J4179_00235) 46545..47873 - 1329 WP_193326606.1 sugar ABC transporter substrate-binding protein -
J4179_RS00240 (J4179_00240) 48102..48947 - 846 WP_208585064.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

Antitoxin VapB-like

(4-79)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13351.28 Da        Isoelectric Point: 4.6533

>T197205 WP_193326609.1 NZ_CP071974:44585-44956 [Trueperella pecoris]
MIVDTSALVAVAYREPGYERITDLLFARNRSKMSVASVLELQLVLRSSELADELIEIFNVDPVGIDVAQLRVARHAAQRF
GKGTGSKAGLNYGDCFSYALAMTAGEPLLFVGEDFTHTDVVVA

Download         Length: 372 bp

>T197205 NZ_CP095776:c4687801-4687268 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9102.22 Da        Isoelectric Point: 4.8660

>AT197205 WP_197551203.1 NZ_CP071974:44346-44588 [Trueperella pecoris]
MPTMNIKDEDVYNAARQLAQLRGTSMTGAVRSAVEEALDAEIKRRERGRLRLAELQDRIAQAAEPRLDESDLYDDRGMPR

Download         Length: 243 bp

>AT197205 NZ_CP095776:c4688078-4687812 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References