Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 50129..50648 Replicon plasmid p1VB13828
Accession NZ_CP071959
Organism Enterococcus faecium strain VB13828

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag J4767_RS13495 Protein ID WP_000588503.1
Coordinates 50391..50648 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag J4767_RS13490 Protein ID WP_000388479.1
Coordinates 50129..50398 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4767_RS13445 (J4767_13445) 45326..46225 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
J4767_RS13450 (J4767_13450) 46228..46713 + 486 WP_002303313.1 single-stranded DNA-binding protein -
J4767_RS15580 46854..46958 - 105 WP_008274030.1 putative holin-like toxin -
J4767_RS13460 (J4767_13460) 47132..47392 + 261 WP_002295623.1 hypothetical protein -
J4767_RS13465 (J4767_13465) 47829..48035 + 207 WP_002347218.1 hypothetical protein -
J4767_RS13470 (J4767_13470) 48035..48286 + 252 WP_002296238.1 hypothetical protein -
J4767_RS13475 (J4767_13475) 48301..48738 + 438 WP_002300851.1 hypothetical protein -
J4767_RS13480 (J4767_13480) 48731..49438 + 708 WP_002303117.1 hypothetical protein -
J4767_RS15585 49603..49803 + 201 WP_002347143.1 hypothetical protein -
J4767_RS13485 (J4767_13485) 49819..49998 + 180 WP_001120991.1 hypothetical protein -
J4767_RS13490 (J4767_13490) 50129..50398 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4767_RS13495 (J4767_13495) 50391..50648 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
J4767_RS13500 (J4767_13500) 51107..51262 + 156 WP_002347142.1 hypothetical protein -
J4767_RS13505 (J4767_13505) 51286..52110 + 825 WP_001809248.1 hypothetical protein -
J4767_RS13510 (J4767_13510) 52275..52889 - 615 WP_001261742.1 recombinase family protein -
J4767_RS13515 (J4767_13515) 53127..53549 + 423 WP_002303116.1 hypothetical protein -
J4767_RS13520 (J4767_13520) 53559..53762 + 204 WP_002299573.1 hypothetical protein -
J4767_RS13525 (J4767_13525) 53973..54557 + 585 WP_002299575.1 recombinase family protein -
J4767_RS13530 (J4767_13530) 54746..55426 - 681 WP_010861579.1 IS6-like element IS1216 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(L) / ant(6)-Ia / aph(3')-III / erm(B) / aac(6')-aph(2'') - 1..296092 296092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T197198 WP_000588503.1 NZ_CP071959:50391-50648 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T197198 NZ_CP095776:326739-327107 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT197198 WP_000388479.1 NZ_CP071959:50129-50398 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT197198 NZ_CP095776:326521-326742 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References