Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2975468..2976073 Replicon chromosome
Accession NZ_CP071957
Organism Alcaligenes faecalis strain JLAF9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5J84_RS13815 Protein ID WP_252605375.1
Coordinates 2975468..2975758 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J5J84_RS13820 Protein ID WP_252605376.1
Coordinates 2975771..2976073 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5J84_RS13800 (J5J84_13800) 2971407..2972882 - 1476 WP_252605374.1 NAD-dependent succinate-semialdehyde dehydrogenase -
J5J84_RS13805 (J5J84_13805) 2973199..2973972 + 774 WP_042487251.1 IclR family transcriptional regulator -
J5J84_RS13810 (J5J84_13810) 2974030..2975418 + 1389 WP_252606581.1 ATP-dependent RNA helicase DbpA -
J5J84_RS13815 (J5J84_13815) 2975468..2975758 + 291 WP_252605375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5J84_RS13820 (J5J84_13820) 2975771..2976073 + 303 WP_252605376.1 putative addiction module antidote protein Antitoxin
J5J84_RS13825 (J5J84_13825) 2976166..2977116 - 951 WP_252605377.1 LysR substrate-binding domain-containing protein -
J5J84_RS13830 (J5J84_13830) 2977502..2978860 + 1359 WP_042487239.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
J5J84_RS13835 (J5J84_13835) 2978857..2979405 + 549 WP_252605378.1 3-phenylpropionate/cinnamic acid dioxygenase subunit beta -
J5J84_RS13840 (J5J84_13840) 2979434..2979754 + 321 WP_026484793.1 bifunctional 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit -
J5J84_RS13845 (J5J84_13845) 2979751..2980566 + 816 WP_252605379.1 3-(cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10998.47 Da        Isoelectric Point: 8.0293

>T197191 WP_252605375.1 NZ_CP071957:2975468-2975758 [Alcaligenes faecalis]
MKTIHTTDTFDRWFSGLRDKQAARRIQVRIDRAEDGNFGDCEPVGEGVSEMRIHYGPGYRVYFVQRELEIVILLAGGNKS
TQNKDIKTALELARQL

Download         Length: 291 bp

>T197191 NZ_CP095774:990455-990745 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10881.57 Da        Isoelectric Point: 5.6998

>AT197191 WP_252605376.1 NZ_CP071957:2975771-2976073 [Alcaligenes faecalis]
MGTIKLRKWDSAEYLQTEEDMVLYLEACMEEAGDDAAFIAKALGNIARAKGMSQLAKETGLGRESLYKALSGEGNPSFGT
ILKVMHALGIKLQPQLVPHN

Download         Length: 303 bp

>AT197191 NZ_CP095774:990159-990458 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References