Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1439145..1439758 Replicon chromosome
Accession NZ_CP071957
Organism Alcaligenes faecalis strain JLAF9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5J84_RS06575 Protein ID WP_252606238.1
Coordinates 1439435..1439758 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5J84_RS06570 Protein ID WP_252606237.1
Coordinates 1439145..1439438 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5J84_RS06550 (J5J84_06545) 1435074..1436321 + 1248 WP_252606233.1 type II secretory pathway protein -
J5J84_RS06555 (J5J84_06550) 1436755..1437000 + 246 WP_252606234.1 EexN family lipoprotein -
J5J84_RS06560 (J5J84_06555) 1436993..1437676 - 684 WP_252606235.1 metallophosphoesterase -
J5J84_RS06565 (J5J84_06560) 1438043..1438762 + 720 WP_252606236.1 hypothetical protein -
J5J84_RS06570 (J5J84_06565) 1439145..1439438 - 294 WP_252606237.1 putative addiction module antidote protein Antitoxin
J5J84_RS06575 (J5J84_06570) 1439435..1439758 - 324 WP_252606238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5J84_RS06580 (J5J84_06575) 1439929..1440927 + 999 WP_252606239.1 taurine ABC transporter substrate-binding protein -
J5J84_RS06585 (J5J84_06580) 1440933..1441718 + 786 WP_252606240.1 taurine ABC transporter ATP-binding subunit -
J5J84_RS06590 (J5J84_06585) 1441735..1442625 + 891 WP_252606241.1 taurine ABC transporter permease TauC -
J5J84_RS06595 (J5J84_06590) 1442675..1443379 - 705 WP_252606242.1 SDR family oxidoreductase -
J5J84_RS06600 (J5J84_06595) 1443484..1444380 + 897 WP_252606243.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(7-102)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12152.02 Da        Isoelectric Point: 10.0308

>T197190 WP_252606238.1 NZ_CP071957:c1439758-1439435 [Alcaligenes faecalis]
MDTINIMNTINRTEAFNTWLSGLKDLRARAKIVIRIKQASLGNFGDVKPISDGVCEMRIHFGPGYRLYYAREGRVVYLLL
SGGDKSSQKQDIKTAIAMWKQIQEDQS

Download         Length: 324 bp

>T197190 NZ_CP095774:990159-990458 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10292.83 Da        Isoelectric Point: 4.8359

>AT197190 WP_252606237.1 NZ_CP071957:c1439438-1439145 [Alcaligenes faecalis]
MTTIKTAPFDAAEYLDSEEAIAEYLSAALEEDDPALFLSALADVVKARGMTKLAKDAGVGRESLYKALAPGAKPRYDTVL
KLARAAGVKLTVEPIHA

Download         Length: 294 bp

>AT197190 NZ_CP095774:990455-990745 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References