Detailed information of TA system TA197188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 6722..7275
• Replicon: plasmid pYL19
• Accession: NZ_CP071956
• Organism: Xanthomonas fragariae strain YL19

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5I97_RS19560
• Protein ID: WP_208591899.1
• Coordinates: 6722..7015 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J5I97_RS19565
• Protein ID: WP_208591900.1
• Coordinates: 7003..7275 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5I97_RS19525	2207..2491	+	285	WP_208591892.1	hypothetical protein	-
J5I97_RS19530	2491..3045	+	555	WP_208591894.1	hypothetical protein	-
J5I97_RS19535	3042..5210	+	2169	WP_208591895.1	DotA/TraY family protein	-
J5I97_RS19540	5222..5731	+	510	WP_208591896.1	hypothetical protein	-
J5I97_RS19545	5790..6005	+	216	WP_208591897.1	hypothetical protein	-
J5I97_RS19550	6014..6367	+	354	WP_208591898.1	hypothetical protein	-
J5I97_RS19555	6397..6591	-	195	WP_208591909.1	hypothetical protein	-
J5I97_RS19560	6722..7015	-	294	WP_208591899.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5I97_RS19565	7003..7275	-	273	WP_208591900.1	CopG family ribbon-helix-helix protein	Antitoxin
J5I97_RS19570	7350..9026	-	1677	WP_208591901.1	relaxase/mobilization nuclease domain-containing protein	-
J5I97_RS19575	9023..9331	-	309	WP_208591903.1	MobB mobilization protein	-
J5I97_RS19580	9617..9907	+	291	WP_208591905.1	hypothetical protein	-
J5I97_RS19585	9904..10206	+	303	WP_208591907.1	hypothetical protein	-
J5I97_RS19590	10722..11090	+	369	WP_208591874.1	hypothetical protein	-
J5I97_RS19595	11293..11825	+	533	Protein_18	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..20156	20156
	-	flank	IS/Tn	-	-	11293..11613	320

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10877.36 Da
• Isoelectric Point: 5.6404

>T197188 WP_208591899.1 NZ_CP071956:c7015-6722 [Xanthomonas fragariae]
VPHVIITEGAGQGLECCRRFLASKSPEAARRAAKAIERQFLLLETTPAIGRPFSEQPEWSELVIEFGDSGYVALYRHEAA
EDVVYVLAFRHQKEVGY

Nucleotide

• Length: 294 bp

>T197188 NZ_CP095774:c147657-147376 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10452.62 Da
• Isoelectric Point: 5.5812

>AT197188 WP_208591900.1 NZ_CP071956:c7275-7003 [Xanthomonas fragariae]
MATSLKIDDELKGRVQHLASLRDRSPHWIMREAIKQYVELEEARESFKQEAQASWIAYQETGRHLTGQEARAWLNTWGTD
NETGLPECHT

Nucleotide

• Length: 273 bp

>AT197188 NZ_CP095774:c147881-147654 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA