Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1535309..1535979 Replicon chromosome
Accession NZ_CP071955
Organism Xanthomonas fragariae strain YL19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5I97_RS07170 Protein ID WP_208590583.1
Coordinates 1535560..1535979 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5I97_RS07165 Protein ID WP_208590581.1
Coordinates 1535309..1535563 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5I97_RS07140 1530570..1531681 - 1112 Protein_1335 IS3 family transposase -
J5I97_RS07150 1532935..1533468 + 534 Protein_1337 transposase -
J5I97_RS07155 1533552..1534046 - 495 WP_208590579.1 hypothetical protein -
J5I97_RS07160 1534616..1534897 + 282 WP_002805735.1 TraK family protein -
J5I97_RS07165 1535309..1535563 + 255 WP_208590581.1 Arc family DNA-binding protein Antitoxin
J5I97_RS07170 1535560..1535979 + 420 WP_208590583.1 type II toxin-antitoxin system VapC family toxin Toxin
J5I97_RS19865 1536312..1536419 + 108 WP_238135662.1 helix-turn-helix domain-containing protein -
J5I97_RS19870 1536658..1536753 + 96 Protein_1343 IS30 family transposase -
J5I97_RS07180 1536903..1537133 + 231 Protein_1344 transposase -
J5I97_RS07185 1537198..1538169 + 972 WP_208590244.1 IS5 family transposase -
J5I97_RS07190 1538298..1538878 + 581 Protein_1346 IS5/IS1182 family transposase -
J5I97_RS07195 1538971..1539345 - 375 WP_208590590.1 Mth938-like domain-containing protein -
J5I97_RS07200 1539362..1539667 - 306 WP_208590591.1 ribosome assembly RNA-binding protein YhbY -
J5I97_RS07205 1539734..1540366 + 633 WP_208590599.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1529298..1538827 9529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14881.06 Da        Isoelectric Point: 4.6936

>T197185 WP_208590583.1 NZ_CP071955:1535560-1535979 [Xanthomonas fragariae]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFSERVLMFDTE
AARNYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNNQ

Download         Length: 420 bp

>T197185 NZ_CP095770:c5220075-5219320 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9466.78 Da        Isoelectric Point: 5.7425

>AT197185 WP_208590581.1 NZ_CP071955:1535309-1535563 [Xanthomonas fragariae]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRVRMGDALAELGRQVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT197185 NZ_CP095770:c5220578-5220210 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTGGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References