Detailed information of TA system TA197183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1022641..1023419
• Replicon: chromosome
• Accession: NZ_CP071955
• Organism: Xanthomonas fragariae strain YL19

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: J5I97_RS04755
• Protein ID: WP_208589526.1
• Coordinates: 1022641..1023132 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: G0CD67
• Locus tag: J5I97_RS04760
• Protein ID: WP_014508712.1
• Coordinates: 1023129..1023419 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5I97_RS04740	1018425..1019330	+	906	WP_208589518.1	30S ribosomal protein S6--L-glutamate ligase	-
J5I97_RS19790	1019553..1019996	+	444	Protein_896	hypothetical protein	-
J5I97_RS04745	1020022..1020699	+	678	WP_003490678.1	response regulator transcription factor	-
J5I97_RS04750	1021158..1022492	+	1335	WP_208589524.1	HAMP domain-containing sensor histidine kinase	-
J5I97_RS04755	1022641..1023132	-	492	WP_208589526.1	GNAT family N-acetyltransferase	Toxin
J5I97_RS04760	1023129..1023419	-	291	WP_014508712.1	DUF1778 domain-containing protein	Antitoxin
J5I97_RS04765	1023495..1023900	-	406	Protein_901	SymE family type I addiction module toxin	-
J5I97_RS04770	1024273..1024605	-	333	WP_208589528.1	hypothetical protein	-
J5I97_RS04775	1025038..1026087	-	1050	Protein_903	RHS repeat-associated core domain-containing protein	-
J5I97_RS04780	1026101..1026340	-	240	WP_208589530.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (26-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17514.19 Da
• Isoelectric Point: 8.9888

>T197183 WP_208589526.1 NZ_CP071955:c1023132-1022641 [Xanthomonas fragariae]
MTVSAPEPLTAHHRVEPFASGLESLDHWLKRRALKNQATGASRTVVACADDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALVQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Nucleotide

• Length: 492 bp

>T197183 NZ_CP095770:2884676-2884957 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10648.20 Da
• Isoelectric Point: 10.5480

>AT197183 WP_014508712.1 NZ_CP071955:c1023419-1023129 [Xanthomonas fragariae]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLIAASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Nucleotide

• Length: 291 bp

>AT197183 NZ_CP095770:2884441-2884686 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Structures

Antitoxin

• AlphaFold DB: A0A3E1LB51