Detailed information of TA system TA197179

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4716976..4717810
• Replicon: chromosome
• Accession: NZ_CP071954
• Organism: Escherichia coli strain SB0258h1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B7MK10
• Locus tag: J5X85_RS22965
• Protein ID: WP_000854820.1
• Coordinates: 4717433..4717810 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: J5X85_RS22960
• Protein ID: WP_001285610.1
• Coordinates: 4716976..4717344 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5X85_RS22925 (4712697)	4712697..4713377	+	681	WP_021515201.1	WYL domain-containing protein	-
J5X85_RS22930 (4713528)	4713528..4714205	+	678	WP_060579144.1	hypothetical protein	-
J5X85_RS22935 (4714211)	4714211..4714444	+	234	WP_000883181.1	DUF905 family protein	-
J5X85_RS22940 (4714534)	4714534..4715352	+	819	WP_104214106.1	DUF932 domain-containing protein	-
J5X85_RS22945 (4715618)	4715618..4716097	+	480	WP_000706978.1	antirestriction protein	-
J5X85_RS22950 (4716112)	4716112..4716588	+	477	WP_001186193.1	RadC family protein	-
J5X85_RS22955 (4716675)	4716675..4716896	+	222	WP_000692347.1	DUF987 domain-containing protein	-
J5X85_RS22960 (4716976)	4716976..4717344	+	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J5X85_RS22965 (4717433)	4717433..4717810	+	378	WP_000854820.1	type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA	Toxin
J5X85_RS22970 (4717807)	4717807..4718004	+	198	Protein_4550	DUF5983 family protein	-
J5X85_RS22975 (4718032)	4718032..4718229	+	198	WP_085949158.1	DUF957 domain-containing protein	-
J5X85_RS22980 (4718314)	4718314..4718874	+	561	Protein_4552	DUF4942 domain-containing protein	-
J5X85_RS22985 (4719709)	4719709..4721247	+	1539	WP_001187178.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4683677..4729060	45383

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14043.12 Da
• Isoelectric Point: 7.8839

>T197179 WP_000854820.1 NZ_CP071954:4717433-4717810 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T197179 NZ_CP095767:2511190-2511927 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT197179 WP_001285610.1 NZ_CP071954:4716976-4717344 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT197179 NZ_CP095767:2512040-2512168 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Toxin

• AlphaFold DB: A0A0E2KXX6