Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4538191..4538713 Replicon chromosome
Accession NZ_CP071954
Organism Escherichia coli strain SB0258h1

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag J5X85_RS22015 Protein ID WP_001105433.1
Coordinates 4538191..4538481 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag J5X85_RS22020 Protein ID WP_000212715.1
Coordinates 4538471..4538713 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5X85_RS22000 (4533359) 4533359..4535014 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
J5X85_RS22005 (4535408) 4535408..4537546 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
J5X85_RS22010 (4537726) 4537726..4538190 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J5X85_RS22015 (4538191) 4538191..4538481 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5X85_RS22020 (4538471) 4538471..4538713 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J5X85_RS22025 (4538905) 4538905..4539291 - 387 WP_001232246.1 cytochrome b562 -
J5X85_RS22030 (4539474) 4539474..4540826 - 1353 WP_001162173.1 metalloprotease PmbA -
J5X85_RS22035 (4540920) 4540920..4541471 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
J5X85_RS22040 (4541621) 4541621..4542994 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T197177 WP_001105433.1 NZ_CP071954:c4538481-4538191 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T197177 NZ_CP095766:c4818063-4817749 [Pseudomonas chengduensis]
ATGATCTTCATCGAAACCCCGATTTTCACTGAGGACGTCAAAGAGCTGTTAAGCGACGATGAGTACCGGGAGTTTCAGCA
GTATCTGGCCGATAACCCCTTAGCCGGGAGAGTGATCACGGAGACCGGCGGCTTACGGAAAGTACGTTGGGGTAGTGCGG
GGCGAGGGAAAAGTGGCGGCGTGAGAGTGATCTACTTCCACGTTGTCGGAGCAAGTCAGATCCGACTGGTGATGATCTAT
CAGAAGGGCATCAAAGACGATCTGAGCAAGGACGAAAAGAAGGCTCTACGCAAAATTATCGAAGGGTGGAAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT197177 WP_000212715.1 NZ_CP071954:c4538713-4538471 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT197177 NZ_CP095766:c4817749-4817459 [Pseudomonas chengduensis]
ATGGAAAAGAACCTGTTTAACCGACTCCTGGAAAGCACCGTACAGATGGATGAAATCGCCCGTGGCGAGCGCCAGCCGTC
CCGGGAATTCCACGTCGATGCTGCCCAGGTTCGCATTATCCGTAAGCGCACGGGTATGGCTCAGCCGGCGTTCGCCGAAG
CCATTGGTGTGGCGCTGGGTACTCTTCGCAACTGGGAACAGGGGCGCCGCGATCCGGAAGGCCCGGCAAAGGCCCTTCTT
CGCGCGATCAGCAACGATCCCCAGAATGTGATAGCCGCGCTGCGGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References