Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5048259..5049480 Replicon chromosome
Accession NZ_CP071947
Organism Pseudomonas aeruginosa strain 2020HL-00861

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5V74_RS23195 Protein ID WP_003114949.1
Coordinates 5048902..5049480 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5V74_RS23190 Protein ID WP_003088112.1
Coordinates 5048259..5048813 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5V74_RS23165 (J5V74_23165) 5043827..5044378 + 552 WP_003102727.1 XRE family transcriptional regulator -
J5V74_RS23170 (J5V74_23170) 5044375..5044773 - 399 WP_003117664.1 NADH-quinone oxidoreductase subunit A -
J5V74_RS23175 (J5V74_23175) 5044786..5045109 - 324 WP_003102734.1 multidrug efflux SMR transporter -
J5V74_RS23180 (J5V74_23180) 5045440..5045901 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
J5V74_RS23185 (J5V74_23185) 5045906..5048101 + 2196 WP_016561792.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
J5V74_RS23190 (J5V74_23190) 5048259..5048813 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
J5V74_RS23195 (J5V74_23195) 5048902..5049480 + 579 WP_003114949.1 HD domain-containing protein Toxin
J5V74_RS23200 (J5V74_23200) 5049589..5050776 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
J5V74_RS23205 (J5V74_23205) 5050766..5052937 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
J5V74_RS23210 (J5V74_23210) 5052927..5054204 - 1278 WP_003160086.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T197150 WP_003114949.1 NZ_CP071947:5048902-5049480 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T197150 NZ_CP095762:350284-350631 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTATGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT197150 WP_003088112.1 NZ_CP071947:5048259-5048813 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT197150 NZ_CP095762:350631-350930 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References