197147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1645065..1645570 Replicon chromosome
Accession NZ_CP071947
Organism Pseudomonas aeruginosa strain 2020HL-00861

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag J5V74_RS07505 Protein ID WP_003121619.1
Coordinates 1645065..1645346 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag J5V74_RS07510 Protein ID WP_003112628.1
Coordinates 1645343..1645570 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5V74_RS07480 (J5V74_07480) 1640316..1641665 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
J5V74_RS07485 (J5V74_07485) 1641714..1642400 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
J5V74_RS07490 (J5V74_07490) 1642501..1643235 + 735 WP_003117208.1 GntR family transcriptional regulator -
J5V74_RS07495 (J5V74_07495) 1643415..1643825 + 411 WP_003101225.1 aegerolysin family protein -
J5V74_RS07500 (J5V74_07500) 1643857..1644765 - 909 WP_016561475.1 LysR family transcriptional regulator -
J5V74_RS07505 (J5V74_07505) 1645065..1645346 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
J5V74_RS07510 (J5V74_07510) 1645343..1645570 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
J5V74_RS07515 (J5V74_07515) 1645746..1646366 - 621 WP_003101226.1 hypothetical protein -
J5V74_RS07520 (J5V74_07520) 1646467..1646967 + 501 WP_003101228.1 LEA type 2 family protein -
J5V74_RS07525 (J5V74_07525) 1647040..1647381 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
J5V74_RS07530 (J5V74_07530) 1647463..1648890 - 1428 WP_003083784.1 GABA permease -
J5V74_RS07535 (J5V74_07535) 1649059..1650552 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T197147 WP_003121619.1 NZ_CP071947:c1645346-1645065 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T197147 NZ_CP095761:4502754-4502972 [Klebsiella michiganensis]
ATGTCTGATAAAATATTAACCAAAGTAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCGGCTGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT197147 WP_003112628.1 NZ_CP071947:c1645570-1645343 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT197147 NZ_CP095761:4502353-4502727 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGGCATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCGACCTCGGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCGGGCAATCGGTT
ATTCCGCTGTTTTGTCAACGCCAGTCGGGAAAACCCGGTCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References