197145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 976955..977561 Replicon chromosome
Accession NZ_CP071936
Organism Helicobacter pylori strain MTT03

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5F39_RS04775 Protein ID WP_078264719.1
Coordinates 977301..977561 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5F39_RS04770 Protein ID WP_078250009.1
Coordinates 976955..977320 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5F39_RS04740 972052..972435 - 384 WP_000410259.1 hypothetical protein -
J5F39_RS04745 972504..972755 - 252 WP_001105124.1 hypothetical protein -
J5F39_RS04750 972752..972961 - 210 WP_000462384.1 hypothetical protein -
J5F39_RS04755 973082..974632 - 1551 WP_283491678.1 helicase C-terminal domain-containing protein -
J5F39_RS04760 974789..976117 - 1329 WP_283491679.1 transposase -
J5F39_RS04765 976154..976570 + 417 WP_000717710.1 IS200/IS605-like element IS606 family transposase -
J5F39_RS04770 976955..977320 + 366 WP_078250009.1 hypothetical protein Antitoxin
J5F39_RS04775 977301..977561 + 261 WP_078264719.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J5F39_RS04780 977667..978191 - 525 WP_001135623.1 acyl-CoA thioesterase -
J5F39_RS04785 978331..979185 + 855 WP_283491680.1 SDR family oxidoreductase -
J5F39_RS04790 979178..980158 + 981 WP_000921452.1 iron ABC transporter permease -
J5F39_RS04795 980158..980925 + 768 WP_000242349.1 ABC transporter ATP-binding protein -
J5F39_RS04800 980989..982110 + 1122 WP_283491681.1 glycosyltransferase family 8 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10109.02 Da        Isoelectric Point: 9.5330

>T197145 WP_078264719.1 NZ_CP071936:977301-977561 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLPPPFKDHALKGVWKPYRECHIKPDVLLVYLVKDDELILLRLG
SHNELF

Download         Length: 261 bp

>T197145 NZ_CP095761:2079579-2079911 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGCGGAAATTTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCAGGGATAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATAGCTGCCCGGAACGGCAAGCGGCTGGAACGCATACCAGACGCTGTGGTAAATGACGTGCTTGCCAGGCTGGATGC
AATTTTTAGTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 14388.36 Da        Isoelectric Point: 8.9643

>AT197145 WP_078250009.1 NZ_CP071936:976955-977320 [Helicobacter pylori]
MPNTTKKDYTQYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKSFTIKLEELNKILQEINKRANDCCFGHET
PNIETQQAMRDAFNKETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 366 bp

>AT197145 NZ_CP095761:2079321-2079578 [Klebsiella michiganensis]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATAGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References