Detailed information of TA system TA197143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 79032..80223
• Replicon: chromosome
• Accession: NZ_CP071936
• Organism: Helicobacter pylori strain MTT03

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: J5F39_RS00395
• Protein ID: WP_078264849.1
• Coordinates: 79032..79796 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: J5F39_RS00400
• Protein ID: WP_078240921.1
• Coordinates: 79786..80223 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5F39_RS00385	76366..77526	+	1161	WP_283491960.1	aminotransferase class V-fold PLP-dependent enzyme	-
J5F39_RS00390	77618..78805	+	1188	WP_283491961.1	transcription termination factor NusA	-
J5F39_RS00395	79032..79796	-	765	WP_078264849.1	hypothetical protein	Toxin
J5F39_RS00400	79786..80223	-	438	WP_078240921.1	Panacea domain-containing protein	Antitoxin
J5F39_RS00405	80742..81272	-	531	WP_078264850.1	hypothetical protein	-
J5F39_RS00410	81273..84806	-	3534	WP_283491962.1	Eco57I restriction-modification methylase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29858.81 Da
• Isoelectric Point: 7.2151

>T197143 WP_078264849.1 NZ_CP071936:c79796-79032 [Helicobacter pylori]
METKEEDRDKKLEEMIVLLCEKGDLSSQTDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLKDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFFKKPIFWFNLMVTILFVIGFC
GELHIIQRLDSKYF

Nucleotide

• Length: 765 bp

>T197143 NZ_CP095760:c1224027-1223281 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGAATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAAGCGGATAAGGACCGCTTGACAGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTTCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17187.31 Da
• Isoelectric Point: 5.7154

>AT197143 WP_078240921.1 NZ_CP071936:c80223-79786 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDEHLVSDDFEAWKYGPVAREVYYKYRNYGANPIDKPKEETL
SQNLRKDELETINCSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDGKEIISKDLIKQEAKQTNGN

Nucleotide

• Length: 438 bp

>AT197143 NZ_CP095760:c1223280-1223110 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA