Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1670646..1671314 | Replicon | chromosome |
| Accession | NZ_CP071917 | ||
| Organism | Streptococcus pneumoniae strain 19A-19339 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | C1C927 |
| Locus tag | J4Q30_RS08605 | Protein ID | WP_001132282.1 |
| Coordinates | 1671135..1671314 (-) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | G0IC64 |
| Locus tag | J4Q30_RS08600 | Protein ID | WP_000961810.1 |
| Coordinates | 1670646..1671098 (-) | Length | 151 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4Q30_RS08580 (J4Q30_08590) | 1667495..1668529 | - | 1035 | WP_000747915.1 | ATP-binding protein | - |
| J4Q30_RS08585 (J4Q30_08595) | 1668663..1668797 | - | 135 | Protein_1712 | 7,8-dihydro-8-oxoguanine-triphosphatase | - |
| J4Q30_RS08590 (J4Q30_08600) | 1668778..1669866 | - | 1089 | WP_000719711.1 | site-2 protease family protein | - |
| J4Q30_RS08595 (J4Q30_08605) | 1669885..1670355 | - | 471 | WP_000257114.1 | DUF3013 family protein | - |
| J4Q30_RS08600 (J4Q30_08610) | 1670646..1671098 | - | 453 | WP_000961810.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J4Q30_RS08605 (J4Q30_08615) | 1671135..1671314 | - | 180 | WP_001132282.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J4Q30_RS08610 (J4Q30_08620) | 1671451..1671630 | - | 180 | WP_001048906.1 | hypothetical protein | - |
| J4Q30_RS08615 (J4Q30_08625) | 1671795..1672034 | - | 240 | WP_000818079.1 | hypothetical protein | - |
| J4Q30_RS08620 (J4Q30_08630) | 1672304..1673575 | + | 1272 | WP_001113206.1 | replication-associated recombination protein A | - |
| J4Q30_RS08630 (J4Q30_08640) | 1674122..1675441 | - | 1320 | WP_000502563.1 | glycoside hydrolase family 32 protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6713.95 Da Isoelectric Point: 11.0174
>T197136 WP_001132282.1 NZ_CP071917:c1671314-1671135 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL
Download Length: 180 bp
>T197136 NZ_CP095742:683090-683611 [Luteibacter aegosomatissinici]
ATGATCATTGCAAACGTCGGAGCAGGATCGCTCCTTGCGTGCTATCGCGTCATAGCTCCGCGCTACGCGACCACGCCACG
TTCAGGGATGGGGGCCGCCCGGAAGGGTGGGCGCTTCAATCGGCCAGGTCAGGAAGCGCTTTATCTCGCTCTCGATGAAG
CCACTGCTCTGGCGGAATACAAGCAGGACAATCCCTGGCTGCCTCCGGGCACGATTTGTACGTTCTTCCTGAACAATATG
AATCTCGCCGATCTGAGCGCGGGCTATGAAGCAGCGCATTGGCCACCTCTTTGGGCGGACTTTGCTATCGATTGGCGAAG
CGAGTGGTTCGGCAGTCATGTTGAGCCGCCCACTTGGTACATGTCTGATGACGTTGTCGCGGCCGGTCTGGACGGCATCA
TCTTCCCATCTCAAGCGCATCCGGGAGGACGGAACCTCGTCGTCTACCGAAGTTCTGAGCGCCCGGCATCTGACTTACAG
GTTTACGACCCCGCGGGTGTCCTACAAACGATAACCCTCTAG
ATGATCATTGCAAACGTCGGAGCAGGATCGCTCCTTGCGTGCTATCGCGTCATAGCTCCGCGCTACGCGACCACGCCACG
TTCAGGGATGGGGGCCGCCCGGAAGGGTGGGCGCTTCAATCGGCCAGGTCAGGAAGCGCTTTATCTCGCTCTCGATGAAG
CCACTGCTCTGGCGGAATACAAGCAGGACAATCCCTGGCTGCCTCCGGGCACGATTTGTACGTTCTTCCTGAACAATATG
AATCTCGCCGATCTGAGCGCGGGCTATGAAGCAGCGCATTGGCCACCTCTTTGGGCGGACTTTGCTATCGATTGGCGAAG
CGAGTGGTTCGGCAGTCATGTTGAGCCGCCCACTTGGTACATGTCTGATGACGTTGTCGCGGCCGGTCTGGACGGCATCA
TCTTCCCATCTCAAGCGCATCCGGGAGGACGGAACCTCGTCGTCTACCGAAGTTCTGAGCGCCCGGCATCTGACTTACAG
GTTTACGACCCCGCGGGTGTCCTACAAACGATAACCCTCTAG
Antitoxin
Download Length: 151 a.a. Molecular weight: 16659.46 Da Isoelectric Point: 3.7220
>AT197136 WP_000961810.1 NZ_CP071917:c1671098-1670646 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
Download Length: 453 bp
>AT197136 NZ_CP095742:682722-683093 [Luteibacter aegosomatissinici]
ATGGTCGCCGTGTTCCAACCGCCGTTGATCGAGCGTTTCCGCGAGTCGGATACTCCGTACCTTTCGCCTGCCAAGGTGGG
GGAGTTTTTTGGGTTCCGGGTGCAGGAGCTGGCTGAGCGGGCCCATGTCCACCGAAATACGCCTACGTCGCGCCCGCAGG
CTCCTCAACTCCAGAAATATCTGCAGGACATGGTTCGCGTTCTGGCGGCGGCAGCCGAGATGACTGGTGACATTGACCGC
GCGGCATTTCTTGTCCGTAACGAGCCACTTCGCGCGTTCGGCTACAAGACGGCCGACATGCTGATCCAGGACGGCAGGAC
CGACGACGTTATTGGATATCTTGAATCGATGGCAGGTGGTGCTGCTGGATGA
ATGGTCGCCGTGTTCCAACCGCCGTTGATCGAGCGTTTCCGCGAGTCGGATACTCCGTACCTTTCGCCTGCCAAGGTGGG
GGAGTTTTTTGGGTTCCGGGTGCAGGAGCTGGCTGAGCGGGCCCATGTCCACCGAAATACGCCTACGTCGCGCCCGCAGG
CTCCTCAACTCCAGAAATATCTGCAGGACATGGTTCGCGTTCTGGCGGCGGCAGCCGAGATGACTGGTGACATTGACCGC
GCGGCATTTCTTGTCCGTAACGAGCCACTTCGCGCGTTCGGCTACAAGACGGCCGACATGCTGATCCAGGACGGCAGGAC
CGACGACGTTATTGGATATCTTGAATCGATGGCAGGTGGTGCTGCTGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7SUI3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 5YRZ | |
| AlphaFold DB | G0IC64 |