Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1633935..1634603 Replicon chromosome
Accession NZ_CP071916
Organism Streptococcus pneumoniae strain 19A-19087

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag J4Q32_RS08340 Protein ID WP_001132282.1
Coordinates 1634424..1634603 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag J4Q32_RS08335 Protein ID WP_000961810.1
Coordinates 1633935..1634387 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4Q32_RS08315 (J4Q32_08320) 1630784..1631818 - 1035 WP_000747915.1 ATP-binding protein -
J4Q32_RS08320 (J4Q32_08325) 1631952..1632086 - 135 Protein_1659 7,8-dihydro-8-oxoguanine-triphosphatase -
J4Q32_RS08325 (J4Q32_08330) 1632067..1633155 - 1089 WP_000719711.1 site-2 protease family protein -
J4Q32_RS08330 (J4Q32_08335) 1633174..1633644 - 471 WP_000257114.1 DUF3013 family protein -
J4Q32_RS08335 (J4Q32_08340) 1633935..1634387 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J4Q32_RS08340 (J4Q32_08345) 1634424..1634603 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
J4Q32_RS08345 (J4Q32_08350) 1634740..1634919 - 180 WP_001048906.1 hypothetical protein -
J4Q32_RS08350 (J4Q32_08355) 1635084..1635323 - 240 WP_000818079.1 hypothetical protein -
J4Q32_RS08355 (J4Q32_08360) 1635593..1636864 + 1272 WP_001113206.1 replication-associated recombination protein A -
J4Q32_RS08365 (J4Q32_08370) 1637411..1638730 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T197134 WP_001132282.1 NZ_CP071916:c1634603-1634424 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T197134 NZ_CP095741:c3223183-3222905 [Luteibacter aegosomaticola]
ATGATTGTTTCGTTCGCGGACAAAGACACGGAAGCCCTGTTTCACGGCCATTGCGAACGCCGCTGGACTTCGATCGGCCG
TGTGGCTCGACGGAAGCTCGTGCAGCTTCATGCAGCCGCGACCCTTTCGTTCCTGGCGAGCCCGCCCGGTAACCGGTTGG
AGCTACTCAAGGGCGGCAGGGCCGGACAGTTCAGCATCCGGATTAACGACCAGTTCCGGGTTTGCTTTTGTTGGGACGAC
GGGCACGCGCACGCCGTCGAAATCGTCGACTATCACTGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT197134 WP_000961810.1 NZ_CP071916:c1634387-1633935 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT197134 NZ_CP095741:c3222895-3222602 [Luteibacter aegosomaticola]
ATGGGCCATCCGCTTCCACCCGTACATCCTGGTGAAGTGCTCCGCGAGGACTTCATGAAGCCCTTTGGGCTTTCGTCAAA
CGCACTCGCCTTGGCGATCGGCGTGACCGCTGCGCGCGTTAATGAGCTCGTATCCGGCAAGCGCGGCATGACTGCCGACA
CGGCGTTGCGCCTGGCGCGCTACTTCGGCACTGATCCGCATAGCTGGATGAACCTGCAGTTGCATTACGAGCTGGAACAG
GCGGAGCGCCGTCTGGGCGATGCGTTGGCCCGCATCCAGCCGCGTGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References