Detailed information of TA system TA197133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 918318..918816
• Replicon: chromosome
• Accession: NZ_CP071916
• Organism: Streptococcus pneumoniae strain 19A-19087

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J4Q32_RS04760
• Protein ID: WP_001812387.1
• Coordinates: 918562..918816 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: J4Q32_RS04755
• Protein ID: WP_000208080.1
• Coordinates: 918318..918560 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4Q32_RS04735 (J4Q32_04730)	914140..915315	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
J4Q32_RS04740 (J4Q32_04735)	915370..916074	+	705	WP_000722076.1	response regulator YycF	-
J4Q32_RS04745 (J4Q32_04740)	916067..917416	+	1350	WP_233923009.1	cell wall metabolism sensor histidine kinase VicK	-
J4Q32_RS04750 (J4Q32_04745)	917418..918227	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
J4Q32_RS04755 (J4Q32_04750)	918318..918560	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
J4Q32_RS04760 (J4Q32_04755)	918562..918816	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J4Q32_RS04765 (J4Q32_04760)	918863..919636	+	774	WP_000731129.1	ion channel	-
J4Q32_RS04770 (J4Q32_04765)	919952..921298	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
J4Q32_RS04775 (J4Q32_04770)	921607..922593	-	987	WP_233923010.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	919952..921298	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T197133 WP_001812387.1 NZ_CP071916:918562-918816 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T197133 NZ_CP095741:c2575886-2575620 [Luteibacter aegosomaticola]
ATGCGCGCTATCAACTATTCCGAGGTCCGGAACAACCTCGCGACCGTCCTTGATACGGTTGTGGACGATGCCGAAGTGGC
GGTGATCACGCGCCGCGGCGACGCCGACGGCAGCCGGGCGGTCTACCTCGTTCCTGCGCGGCTGTGGGAAAGCATGGAGG
AAACCGCCTACCTTCTCTCCGGCGCGAACCGCGGCCACATCCTCGAAAGCCTGCGCCAGGCGCGGGCGGGCGAAGTGTTC
GAGCGGCCGTTGATTGAAGACGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT197133 WP_000208080.1 NZ_CP071916:918318-918560 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT197133 NZ_CP095741:c2575613-2575350 [Luteibacter aegosomaticola]
ATGGCACGGAAGCTCACATTTACGTCAAAAGGCTGGGCCGACTACGCGTCCTGGGCAGACGATCGCAAGATGCTCGCCCG
CGTGAACCTGCTAATCAGGGAGTGCCTGCGCACGCCCACTGAGGGCCTGGCCAAACCAAAGCCGATGCGCGGCGATCTTG
CCGGCGCCTGGTCGCGGCGCATCGATGAGAGGCACCGCCTGGTCTATCTGTTCACCGACCACGAACTCGAAGTGATCGCG
TGCCGCCTGCATACGACGGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7