Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 53437..54078 Replicon plasmid unnamed1
Accession NZ_CP071900
Organism Pseudomonas stutzeri isolate TPA3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J4H94_RS21010 Protein ID WP_088192771.1
Coordinates 53896..54078 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J4H94_RS21005 Protein ID WP_088192770.1
Coordinates 53437..53859 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H94_RS20980 48600..49130 - 531 WP_208218800.1 hypothetical protein -
J4H94_RS20985 49161..51374 - 2214 WP_208218802.1 hypothetical protein -
J4H94_RS20990 51623..52162 + 540 WP_088192768.1 hypothetical protein -
J4H94_RS20995 52311..52826 + 516 WP_208218901.1 hypothetical protein -
J4H94_RS21000 52965..53276 - 312 WP_208218804.1 hypothetical protein -
J4H94_RS21005 53437..53859 - 423 WP_088192770.1 HicB family protein Antitoxin
J4H94_RS21010 53896..54078 - 183 WP_088192771.1 type II toxin-antitoxin system HicA family toxin Toxin
J4H94_RS21015 54343..55308 + 966 WP_208218806.1 DNA-binding protein -
J4H94_RS21020 55498..55635 - 138 WP_208218808.1 hypothetical protein -
J4H94_RS21025 55874..56401 - 528 WP_208218810.1 hypothetical protein -
J4H94_RS21030 56417..56773 - 357 WP_208218811.1 hypothetical protein -
J4H94_RS21035 56783..57364 - 582 WP_208218813.1 hypothetical protein -
J4H94_RS21040 57377..57727 - 351 WP_088192782.1 hypothetical protein -
J4H94_RS21045 57986..58372 - 387 WP_208218815.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82083 82083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6909.97 Da        Isoelectric Point: 10.4140

>T197127 WP_088192771.1 NZ_CP071900:c54078-53896 [Pseudomonas stutzeri]
MKYSEFRRWLKAQGVSFEPAKGSHFKAYFGDRQTIVPDHGSKEIGEGLRKKILKDLGLKE

Download         Length: 183 bp

>T197127 NZ_CP095741:768937-769788 [Luteibacter aegosomaticola]
ATGATGGACCTCGCCGTCTCTATCGCGCATCGGCTGCGGAATCACGCGGCTGAAAATCAGCAAGACTTCAATGCGGTGCT
CACGCGATTTGCCTCTGAGCGTCTTCTTTTCCGTCTGTCGCAGTCGGAACACGCCAAGAGCTTCCTGCTGAAGGGTGCGT
TGCTTTTCCTGCTATGGCATGACCTTCCTGAACGTCCGACCCGTGATATCGATCTCCTGGGTTTCGGAGAGGAAGACGTG
GAGTCCATCGAGTCGATATTTCGGGAGGTATGCGCGATCGATGCCTCCGATGCGGTCGTCTTTGAGCCGGCATCAGTCAG
AGGGGCGACCATCCGCAAGCAGGCAGGGTACGGCGGAGTCCGCATAACGCTGCTGGGTAAGCTGAAGAATGTCCGGCTTC
ACGTGCAGGTCGATGTGGGCTTCGGCGATGCCGTGACTCCTGCCGCATCTGAGGAAGTATTTCCGGTCGTCCTCGCCGAC
CTTCCCGCACCGATCCTACGGGTCTACCCGAAGTACACCGTATGTGCGGAAAAACTTGAGGCGATAAGCGCATTGGGAAT
GGCGAATACGCGCCTGAAGGACTTCTACGATATGTGGTTGCTCCTGACACCACGCGACATGGACGACGATATGCTTGGAT
CTGCTATCGCTGCTACCTTCAACCGCCGGAAGCGGCCCATCGGGGATGAATGGCCGGTAGGTCTAACCGACGAGTTTGCA
GCCGATTCTCAGAGGCAGAGACAATGGCAGGCCTTCCTTGCCAAGAATGGACTCGTTGCCCCGCCACTGTCGGACGTGTT
GGCAACGCTTCGCCATTGCCTGTCGGTTCCACTGGATAAGGCGCGAAAATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15127.37 Da        Isoelectric Point: 4.7323

>AT197127 WP_088192770.1 NZ_CP071900:c53859-53437 [Pseudomonas stutzeri]
MFDYPVIVHQEDGCVWISSDDVPELNSAGDNEAEALLDAVDGLESALSLYVDQRRAVPLPSPAKPGQPVVRLPALTAAKV
ALWNAMCAQGVGKAEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALAILGQRLEISVIAA

Download         Length: 423 bp

>AT197127 NZ_CP095741:768315-768923 [Luteibacter aegosomaticola]
ATGCCCAGAAAAATCGCAGAAGATCAGATCCTTGCTCTCGCGCGCGACGTGGGTGTGATCCGTGCGCGCGATATCGCGGC
CCGCGGAATCCCGACGGTAGTCCTGAGTCGTATGGTGGCTGCTGGTCAACTCGAGCGGGTGTCTCGTGGCCTCTACACTC
ATCCCGGCACCTCGCCTAGCGAGCATCGTTCGCTTGCCGAGGTGGCGGCCCGCATTCCTTCGGGCGTCGTATGCCTGCTG
ACGGCGCTAAGGTATTACGGCATAGGGACGCAGTCGCCTCTTGCCGTTTGGGTCGCTATTCCATCTCAAGCGCCTACGCC
GCGTCTCGCGCACGTGCGGATCCGCTACGTATGGATGACACCCTCGCCCCTCACCGAAGGCGTAACTGAGGTCAACATCG
AAGGCGTCAGCGTGAAAGTCTTCAGCATCGCGAAGACCATTGCCGATTGCTTCAAGTTTCGAAACAAGATCGGACTGGAC
GTCGCCGTCGAGGCGCTGGCGGACGCCTGGCGCCGAGATCTTGTTTCCATGGACGACCTTTGGCGCTTTGCGAAGATCGA
TCGGGTTGCCAACGTCATGCGGCCGTACCTTGAGTCGCTGACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References