Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3431922..3432579 Replicon chromosome
Accession NZ_CP071876
Organism Enterobacter hormaechei strain GX4-8L

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag J4O68_RS16540 Protein ID WP_022649305.1
Coordinates 3432169..3432579 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag J4O68_RS16535 Protein ID WP_003863437.1
Coordinates 3431922..3432188 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4O68_RS16515 (J4O68_16500) 3427354..3428787 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
J4O68_RS16520 (J4O68_16505) 3428904..3429635 - 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
J4O68_RS16525 (J4O68_16510) 3429902..3430561 + 660 WP_003863433.1 hemolysin III family protein -
J4O68_RS16530 (J4O68_16515) 3430647..3431627 - 981 WP_058656478.1 tRNA-modifying protein YgfZ -
J4O68_RS16535 (J4O68_16520) 3431922..3432188 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
J4O68_RS16540 (J4O68_16525) 3432169..3432579 + 411 WP_022649305.1 protein YgfX Toxin
J4O68_RS16545 (J4O68_16530) 3432581..3433102 - 522 WP_003863440.1 flavodoxin FldB -
J4O68_RS16550 (J4O68_16535) 3433204..3434100 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
J4O68_RS16555 (J4O68_16540) 3434129..3434842 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J4O68_RS16560 (J4O68_16545) 3434848..3436581 + 1734 WP_058658593.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T197104 WP_022649305.1 NZ_CP071876:3432169-3432579 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T197104 NZ_CP095557:c3908811-3908494 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT197104 WP_003863437.1 NZ_CP071876:3431922-3432188 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT197104 NZ_CP095557:c3908501-3908214 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References