Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2219802..2220398 Replicon chromosome
Accession NZ_CP071876
Organism Enterobacter hormaechei strain GX4-8L

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J4O68_RS10780 Protein ID WP_023295756.1
Coordinates 2219802..2220104 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag J4O68_RS10785 Protein ID WP_023295755.1
Coordinates 2220111..2220398 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4O68_RS10760 (J4O68_10745) 2216021..2217370 + 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -
J4O68_RS10765 (J4O68_10750) 2217464..2218408 + 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
J4O68_RS10770 (J4O68_10755) 2218459..2218731 + 273 WP_017382612.1 DUF3811 domain-containing protein -
J4O68_RS10775 (J4O68_10760) 2218732..2219604 - 873 WP_235155509.1 23S rRNA pseudouridine(2604) synthase RluF -
J4O68_RS10780 (J4O68_10765) 2219802..2220104 + 303 WP_023295756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4O68_RS10785 (J4O68_10770) 2220111..2220398 + 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
J4O68_RS10790 (J4O68_10775) 2220395..2222026 - 1632 WP_003860350.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.24 Da        Isoelectric Point: 10.1042

>T197102 WP_023295756.1 NZ_CP071876:2219802-2220104 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T197102 NZ_CP095557:1973500-1973602 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT197102 WP_023295755.1 NZ_CP071876:2220111-2220398 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT197102 NZ_CP095557:c1973609-1973464 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References