Detailed information of TA system TA197101

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1462734..1463416
• Replicon: chromosome
• Accession: NZ_CP071876
• Organism: Enterobacter hormaechei strain GX4-8L

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: J4O68_RS07135
• Protein ID: WP_235155439.1
• Coordinates: 1462734..1463075 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: J4O68_RS07140
• Protein ID: WP_235155440.1
• Coordinates: 1463096..1463416 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4O68_RS07100 (J4O68_07085)	1458823..1459014	+	192	WP_071785715.1	YecR family lipoprotein	-
J4O68_RS07105 (J4O68_07090)	1459037..1459393	-	357	WP_032608610.1	hypothetical protein	-
J4O68_RS07110 (J4O68_07095)	1459396..1459938	-	543	WP_032608608.1	type IV secretion protein Rhs	-
J4O68_RS07115 (J4O68_07100)	1460044..1460202	-	159	WP_023315491.1	hypothetical protein	-
J4O68_RS07120 (J4O68_07105)	1460554..1460820	-	267	WP_235155437.1	hypothetical protein	-
J4O68_RS07125 (J4O68_07110)	1461085..1461699	-	615	WP_220721905.1	hypothetical protein	-
J4O68_RS07130 (J4O68_07115)	1461731..1462501	-	771	WP_235155438.1	hypothetical protein	-
J4O68_RS07135 (J4O68_07120)	1462734..1463075	-	342	WP_235155439.1	TA system toxin CbtA family protein	Toxin
J4O68_RS07140 (J4O68_07125)	1463096..1463416	-	321	WP_235155440.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J4O68_RS07145 (J4O68_07130)	1463435..1463656	-	222	WP_235155441.1	DUF987 domain-containing protein	-
J4O68_RS07150 (J4O68_07135)	1463665..1464147	-	483	WP_235155442.1	DNA repair protein RadC	-
J4O68_RS07155 (J4O68_07140)	1464156..1464620	-	465	WP_235155443.1	antirestriction protein	-
J4O68_RS07160 (J4O68_07145)	1464762..1467605	-	2844	WP_235155444.1	Ag43/Cah family autotransporter adhesin	-
J4O68_RS07165 (J4O68_07150)	1467678..1468364	-	687	WP_235155445.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1458498..1490467	31969

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12758.84 Da
• Isoelectric Point: 8.0566

>T197101 WP_235155439.1 NZ_CP071876:c1463075-1462734 [Enterobacter hormaechei]
MKTLPATISQAAKPCLSPVAVWQMLLIRLLEQHYGLTLNDTPFSDETVIKEHIDAGISLANAVNFLVEKYELVRIDRRGF
NRQEQSPYLLAVDILRARQAIGLLRQNHPPSIP

Nucleotide

• Length: 342 bp

>T197101 NZ_CP095557:791959-792369 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11850.42 Da
• Isoelectric Point: 6.4742

>AT197101 WP_235155440.1 NZ_CP071876:c1463416-1463096 [Enterobacter hormaechei]
MSSNVTWGLQRNISPLLEAHLVQGGNRLHYLADRASITGKFSDDECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTIY
HNGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 321 bp

>AT197101 NZ_CP095557:791712-791978 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA