Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 133554..134293 Replicon chromosome
Accession NZ_CP071876
Organism Enterobacter hormaechei strain GX4-8L

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag J4O68_RS00630 Protein ID WP_032609220.1
Coordinates 133808..134293 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag J4O68_RS00625 Protein ID WP_003857131.1
Coordinates 133554..133820 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4O68_RS00605 (J4O68_00610) 129030..130016 + 987 WP_022651202.1 DUF979 domain-containing protein -
J4O68_RS00610 (J4O68_00615) 130026..131021 + 996 WP_063868602.1 DUF2891 domain-containing protein -
J4O68_RS00615 (J4O68_00620) 131043..132431 - 1389 WP_023314162.1 MFS transporter -
J4O68_RS00620 (J4O68_00625) 132561..133490 + 930 WP_045349966.1 LysR family transcriptional regulator -
J4O68_RS00625 (J4O68_00630) 133554..133820 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
J4O68_RS00630 (J4O68_00635) 133808..134293 + 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
J4O68_RS00635 (J4O68_00640) 134471..135763 - 1293 WP_045896810.1 glycosyl hydrolase family 28 protein -
J4O68_RS00640 (J4O68_00645) 135868..136626 - 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
J4O68_RS00645 (J4O68_00650) 136713..137297 + 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
J4O68_RS00650 (J4O68_00655) 137382..138140 + 759 WP_023314159.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T197098 WP_032609220.1 NZ_CP071876:133808-134293 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T197098 NZ_CP095556:c676219-675809 [Pseudomonas mosselii]
ATGCTCAGGTACATGCTCGATACCAACATCTGCATCTTCACCATCAAGAACAAGCCACAAGTGGTGCGCGAGGCATTCAA
TCGGCACCACGGCCAGTTGGCCATCAGCACGGTAACCCTGATGGAGTTGATCTACGGTGCGGAAAAGTCCGCCGCGCCGG
AGCGTAATCTGGCCATTGTCGAGGGGTTCGCCGCACGGCTCGATGTGCTTGACTACGACATTCAGGGCGCAGCTCACACC
GCGCAGCTACGTGCGGAACTGGCCAAGGCCGGCACGCCCATCGGCCCCTACGACAGAATGATTGCCGGCCACGCCCGCGC
GCGCGGCCTCACGCTGGTGACCAACAACCTGCGCGAGTTCCAGCGTGTTCCGGGGCTGCGTGTGGAAGATTGGGTGACAC
ATCCACGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT197098 WP_003857131.1 NZ_CP071876:133554-133820 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT197098 NZ_CP095556:c676449-676219 [Pseudomonas mosselii]
ATGGAGCAAGGTGCAGTCTTCAAAAGCAACCGCAGCCAGGCTATCCGCATGCCAAAAGCCCTCGCCCTTCCAGAAGACGT
CACCCGAGTGGACATCGTCGCGGTGGGCCGTTCCCGTATCATCTCGCCTGCCGGCGAAAGCTGGGACAGCTGGTTCGAGG
GTGACGATGTGAGTTCGGACTTCATGGCGAGCAGGGAACAGCCAGCCGACCAGGAGCGCGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References