Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 6835497..6836061 Replicon chromosome
Accession NZ_CP071872
Organism Streptomyces formicae strain 1H-GS9

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J4032_RS30680 Protein ID WP_242336413.1
Coordinates 6835497..6835844 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag J4032_RS30685 Protein ID WP_242336416.1
Coordinates 6835831..6836061 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4032_RS30670 (J4032_30315) 6830915..6834229 + 3315 WP_242336407.1 S8 family serine peptidase -
J4032_RS30675 (J4032_30320) 6834410..6835438 + 1029 WP_242336410.1 aspartate-semialdehyde dehydrogenase -
J4032_RS30680 (J4032_30325) 6835497..6835844 - 348 WP_242336413.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J4032_RS30685 (J4032_30330) 6835831..6836061 - 231 WP_242336416.1 antitoxin Antitoxin
J4032_RS30690 (J4032_30335) 6836162..6838729 + 2568 WP_242336419.1 aminopeptidase N -
J4032_RS30695 (J4032_30340) 6838944..6840434 + 1491 WP_242336422.1 ATP-binding protein -
J4032_RS30700 (J4032_30345) 6840431..6840841 + 411 WP_242336425.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12772.63 Da        Isoelectric Point: 10.5604

>T197096 WP_242336413.1 NZ_CP071872:c6835844-6835497 [Streptomyces formicae]
MRRGDIYMVDLEPARGSEANKVRPAVIVSNDGANQSVERNDRGVVTVAPLTSNTTRVLTFQVLLPADESRLPKDSKVQCE
QVRAVAPERILQRVGSVPRQRMAEIDTALRRHLAL

Download         Length: 348 bp

>T197096 NZ_CP095552:c2913397-2913107 [Gordonia hongkongensis]
GTGAGCGACAACCCCACGGACTCGGCCGATGAGTACCGCGTCGAGGTCGCATCCCCCGCACGCCGCGATCTGCAACGCCT
TCCATCCCGGATCGTCCACGCTGTCATCGAGTTCATCTCCGGGCCCCTCGCCGGCAACCCGCACCGCCTCAGCAAACCGC
TACGCGACGACCTCGAAGGCCTTCACAGCGCACGCCGCGGCGACTACCGCATCCTGCTGCGCATCGACGATCCCCACCAC
ACCATCGTCATCGTCAAGATCGACCACCGAGCCCACGCCTACCGCACCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8447.15 Da        Isoelectric Point: 3.7615

>AT197096 WP_242336416.1 NZ_CP071872:c6836061-6835831 [Streptomyces formicae]
VKISVSLPQEDVAFVDEYVTRTEAESRSAVIHAAIELLRAAQLEAEYTEAFAEWDASEDAALWDRTSGDGITDETW

Download         Length: 231 bp

>AT197096 NZ_CP095552:c2913669-2913394 [Gordonia hongkongensis]
ATGACGACAGTGCCACTCGGTGAAGCCAAGGACAAGCTCTCCGCGCTCATCGACAGCGCCGAAACCACGCACGACATCAT
CACGATCACCAAACACGGCAAACCTGCCGCGGTGCTCATGTCGGCTGACGACCTCGAATCGCTGCACGAAACGATCTACT
GGCTCTCACGCGCCGGCATCCGCGAAGCTGTGGCGGCTGCCGACGTCGAGTACGCCGCCGGCCAAACCGTTTCCCTCGAG
GACCTGCGCGTCGAACACGGCATGCCGCCCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References