Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1630398..1630930 Replicon chromosome
Accession NZ_CP071872
Organism Streptomyces formicae strain 1H-GS9

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4032_RS07545 Protein ID WP_242329935.1
Coordinates 1630398..1630655 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4032_RS07550 Protein ID WP_242329936.1
Coordinates 1630652..1630930 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4032_RS07515 (J4032_07440) 1625672..1626316 + 645 WP_242329930.1 DUF6230 family protein -
J4032_RS07520 (J4032_07445) 1626411..1626959 + 549 WP_242329931.1 DUF6114 domain-containing protein -
J4032_RS07525 (J4032_07450) 1626949..1628199 + 1251 WP_242329932.1 hypothetical protein -
J4032_RS07530 (J4032_07455) 1628365..1628727 + 363 WP_242329933.1 hypothetical protein -
J4032_RS07535 (J4032_07460) 1629051..1629632 - 582 WP_242338983.1 XRE family transcriptional regulator -
J4032_RS07540 (J4032_07465) 1629916..1630140 + 225 WP_242329934.1 hypothetical protein -
J4032_RS07545 (J4032_07470) 1630398..1630655 - 258 WP_242329935.1 Txe/YoeB family addiction module toxin Toxin
J4032_RS07550 (J4032_07475) 1630652..1630930 - 279 WP_242329936.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4032_RS07555 (J4032_07480) 1631135..1631797 + 663 WP_242329937.1 hypothetical protein -
J4032_RS07560 (J4032_07485) 1631752..1632528 + 777 WP_242329938.1 O-antigen ligase family protein -
J4032_RS07565 (J4032_07490) 1632680..1633162 + 483 WP_242329939.1 prevent-host-death family protein -
J4032_RS07570 (J4032_07495) 1633529..1634962 - 1434 WP_242329940.1 pyruvate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10221.63 Da        Isoelectric Point: 9.8745

>T197095 WP_242329935.1 NZ_CP071872:c1630655-1630398 [Streptomyces formicae]
VRDVRFRPTGWEDYVYWQTANKQLAKKINRLIGEIQRDPFTGIGKPEPLKGDLSGYWSRRIDDEHRLIYRADDKEVVIIK
ARYHY

Download         Length: 258 bp

>T197095 NZ_CP095552:1323614-1324018 [Gordonia hongkongensis]
TTGATCTATCTCGACACCTCGGCGATGGTGAAACTCGTGGTGCGCGAGGCGGAGACCGCACCGCTGATCGAGTGGCTCGG
GAAGTATCCCGGGGTCCCGATCGTGACGAGTGCGCTGGGACGGGTCGAATTGATGCGCACGGCCTTGCATGATGGCAGTC
CGGGCCTTCAGGAGCGAGCGCGTGATCTTCTCGATTCTCTGGACGTCGTCCCGCTCAGCGACGCCGTCATCGACATCGCC
GAATCGATCGGCCCGTCTTCGCTCCGTTCGCTCGACGCGTTGCATCTGGCCTCTGCCAGCGTGATTCGCGCTGAGATGAG
CGCATTTGTGGCCTACGACCATCGACTCATCGCAGGCGCGTCCGCGCTCGGCTATCCGACCGTCGCTCCGGGCGCCGAGT
TGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9968.14 Da        Isoelectric Point: 4.0936

>AT197095 WP_242329936.1 NZ_CP071872:c1630930-1630652 [Streptomyces formicae]
VAITATEARAKLFPLIQQVNDDHEPVEITSKGGNAVLMSADDYHSWQETVYLLRSPANAAHLMAAIAADKAADTPVIEKT
MEDLEAMTEGEE

Download         Length: 279 bp

>AT197095 NZ_CP095552:1323345-1323617 [Gordonia hongkongensis]
ATGAGGACGATCGGTATCCGCGAGCTCAGGCAGCACGCCTCGCAGTATCTGGCGCAAGTCGAGGCCGGGGAAGAGTTGGC
CATCACCAACCGAGGCCGCACGGTTGCGCGGTTGGTCCCGGTGTCTGCCGGGGAACGCAGCAGAGACGCGCTCATCGAGG
CCGGGATACTCGTGCCGGCCCGCCGTGCGGGCGGCATAACCGGGCTGCACCCCGAGACGTTGCCGACGCGCGCGCTCACC
GAAGTCCTCGAGCAGGTTCGCGAGGATCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References