Detailed information of TA system TA197094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1199649..1200147
• Replicon: chromosome
• Accession: NZ_CP071871
• Organism: Streptococcus pneumoniae strain BVJ1JL

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C1CEI0
• Locus tag: JN057_RS06100
• Protein ID: WP_001823540.1
• Coordinates: 1199649..1199903 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN057_RS06105
• Protein ID: WP_012677101.1
• Coordinates: 1199905..1200147 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN057_RS06085 (JN057_01257)	1194921..1197389	-	2469	WP_001152988.1	DNA gyrase subunit A	-
JN057_RS06090 (JN057_01258)	1197583..1198569	+	987	WP_000204727.1	L-lactate dehydrogenase	-
JN057_RS06095 (JN057_01259)	1198859..1199602	-	744	WP_000725952.1	ion channel	-
JN057_RS06100 (JN057_01260)	1199649..1199903	-	255	WP_001823540.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN057_RS06105 (JN057_01261)	1199905..1200147	-	243	WP_012677101.1	DUF6290 family protein	Antitoxin
JN057_RS06110 (JN057_01262)	1200238..1201047	-	810	WP_001289496.1	MBL fold metallo-hydrolase	-
JN057_RS06115 (JN057_01263)	1201049..1202398	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
JN057_RS06120 (JN057_01264)	1202391..1203095	-	705	WP_000722076.1	response regulator YycF	-
JN057_RS06125 (JN057_01265)	1203151..1204326	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
JN057_RS11590	1204423..1204548	+	126	WP_001818232.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10040.76 Da
• Isoelectric Point: 10.9371

>T197094 WP_001823540.1 NZ_CP071871:c1199903-1199649 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T197094 NZ_CP095541:121435-121740 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9204.47 Da
• Isoelectric Point: 4.1051

>AT197094 WP_012677101.1 NZ_CP071871:c1200147-1199905 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVANLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT197094 NZ_CP095541:121215-121433 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: C1CEI0