Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 998523..999757 | Replicon | chromosome |
| Accession | NZ_CP071871 | ||
| Organism | Streptococcus pneumoniae strain BVJ1JL | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | E6Y3Z8 |
| Locus tag | JN057_RS05180 | Protein ID | WP_000405369.1 |
| Coordinates | 998999..999757 (+) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | JN057_RS05175 | Protein ID | WP_000579623.1 |
| Coordinates | 998523..998999 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN057_RS05125 (JN057_01051) | 993759..994043 | + | 285 | WP_000969641.1 | DUF5962 family protein | - |
| JN057_RS05130 (JN057_01052) | 994057..994353 | + | 297 | WP_000998891.1 | DUF5966 family protein | - |
| JN057_RS05135 (JN057_01053) | 994367..994564 | - | 198 | WP_004249782.1 | hypothetical protein | - |
| JN057_RS05140 (JN057_01054) | 994724..995365 | + | 642 | WP_000933082.1 | hypothetical protein | - |
| JN057_RS05145 (JN057_01055) | 995375..996460 | + | 1086 | WP_001019160.1 | toprim domain-containing protein | - |
| JN057_RS05150 (JN057_01056) | 996511..996744 | + | 234 | WP_000152419.1 | DUF5965 family protein | - |
| JN057_RS05155 (JN057_01057) | 996741..997124 | + | 384 | WP_000159216.1 | DUF5945 family protein | - |
| JN057_RS05160 (JN057_01058) | 997163..997438 | + | 276 | WP_000495442.1 | hypothetical protein | - |
| JN057_RS05165 (JN057_01059) | 997520..998152 | + | 633 | WP_000424174.1 | DUF3990 domain-containing protein | - |
| JN057_RS05170 (JN057_01060) | 998143..998370 | + | 228 | WP_000301902.1 | hypothetical protein | - |
| JN057_RS05175 (JN057_01061) | 998523..998999 | + | 477 | WP_000579623.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| JN057_RS05180 (JN057_01062) | 998999..999757 | + | 759 | WP_000405369.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| JN057_RS05185 (JN057_01063) | 1000233..1000754 | + | 522 | WP_243749657.1 | hypothetical protein | - |
| JN057_RS05190 (JN057_01064) | 1000895..1002241 | + | 1347 | WP_001808790.1 | IS1380-like element ISSpn5 family transposase | - |
| JN057_RS05195 | 1002508..1002729 | + | 222 | WP_050284786.1 | hypothetical protein | - |
| JN057_RS05200 (JN057_01065) | 1002968..1003216 | + | 249 | WP_001814254.1 | hypothetical protein | - |
| JN057_RS05205 (JN057_01066) | 1003387..1004106 | + | 720 | Protein_1042 | type A chloramphenicol O-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(M) / cat(pC194) | - | 963639..1015409 | 51770 | |
| - | flank | IS/Tn | cat(pC194) | - | 1000895..1004037 | 3142 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28911.84 Da Isoelectric Point: 7.5459
>T197091 WP_000405369.1 NZ_CP071871:998999-999757 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
Download Length: 759 bp
>T197091 NZ_CP095540:c4507962-4507660 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18259.71 Da Isoelectric Point: 4.4258
>AT197091 WP_000579623.1 NZ_CP071871:998523-998999 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT197091 NZ_CP095540:c4507624-4507283 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|