Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3372765..3373338 Replicon chromosome
Accession NZ_CP071870
Organism Propioniciclava sp. MC1595

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J4N02_RS16320 Protein ID WP_188334792.1
Coordinates 3372765..3373115 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag J4N02_RS16325 Protein ID WP_223202756.1
Coordinates 3373099..3373338 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N02_RS16305 (J4N02_16305) 3367987..3369544 + 1558 Protein_3233 IS1634 family transposase -
J4N02_RS16310 (J4N02_16310) 3369788..3371929 - 2142 WP_188334790.1 CHAT domain-containing protein -
J4N02_RS16315 (J4N02_16315) 3372127..3372396 - 270 WP_223202757.1 hypothetical protein -
J4N02_RS16320 (J4N02_16320) 3372765..3373115 - 351 WP_188334792.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J4N02_RS16325 (J4N02_16325) 3373099..3373338 - 240 WP_223202756.1 ribbon-helix-helix domain-containing protein Antitoxin
J4N02_RS16330 (J4N02_16330) 3373717..3375918 + 2202 WP_188334788.1 hypothetical protein -
J4N02_RS16335 (J4N02_16335) 3375980..3376258 + 279 WP_188334787.1 helix-turn-helix domain-containing protein -
J4N02_RS16340 (J4N02_16340) 3376451..3377203 - 753 WP_208091035.1 ATP-binding protein -
J4N02_RS16345 (J4N02_16345) 3377290..3378024 - 735 Protein_3241 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12559.60 Da        Isoelectric Point: 11.1986

>T197090 WP_188334792.1 NZ_CP071870:c3373115-3372765 [Propioniciclava sp. MC1595]
MMLRGEIRLVDLEPARAGEADKRRPAVIVSNDNANAIAARLGRGVVTVVPVTSNIARVFPFQVLLSAHETGIHVDSKAQA
EQVRSVSVARLGPVIGRIPTHLMSQLDDALRLHLQL

Download         Length: 351 bp

>T197090 NZ_CP095540:3684769-3684876 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8320.08 Da        Isoelectric Point: 4.0197

>AT197090 WP_223202756.1 NZ_CP071870:c3373338-3373099 [Propioniciclava sp. MC1595]
MGQVKLSVSLSESEVAALDKYAHAAGLKSRSAAIQQAIRLLGDAELQTAYEAAWQEWEDSGDADAWDSAAADGLADAPR

Download         Length: 240 bp

>AT197090 NZ_CP095540:c3684712-3684657 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References