Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3359783..3360327 Replicon chromosome
Accession NZ_CP071870
Organism Propioniciclava sp. MC1595

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4N02_RS16265 Protein ID WP_188334800.1
Coordinates 3359783..3360049 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4N02_RS16270 Protein ID WP_208091032.1
Coordinates 3360046..3360327 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N02_RS16240 (J4N02_16240) 3354852..3356159 + 1308 WP_188334806.1 sugar ABC transporter substrate-binding protein -
J4N02_RS16245 (J4N02_16245) 3356217..3357149 + 933 WP_188334805.1 sugar ABC transporter permease -
J4N02_RS16250 (J4N02_16250) 3357146..3358063 + 918 WP_182818758.1 carbohydrate ABC transporter permease -
J4N02_RS16255 (J4N02_16255) 3358065..3359048 + 984 WP_182818756.1 family 43 glycosylhydrolase -
J4N02_RS16260 (J4N02_16260) 3359237..3359731 + 495 WP_182818908.1 hypothetical protein -
J4N02_RS16265 (J4N02_16265) 3359783..3360049 - 267 WP_188334800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N02_RS16270 (J4N02_16270) 3360046..3360327 - 282 WP_208091032.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4N02_RS16275 (J4N02_16275) 3360587..3361999 - 1413 WP_182818841.1 ferredoxin reductase family protein -
J4N02_RS16280 (J4N02_16280) 3362027..3362605 - 579 WP_208091033.1 TetR/AcrR family transcriptional regulator -
J4N02_RS16285 (J4N02_16285) 3362605..3363207 - 603 WP_182818838.1 class I SAM-dependent methyltransferase -
J4N02_RS16290 (J4N02_16290) 3363314..3364804 + 1491 WP_182818837.1 FAD-dependent monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-76)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 9863.48 Da        Isoelectric Point: 10.7805

>T197089 WP_188334800.1 NZ_CP071870:c3360049-3359783 [Propioniciclava sp. MC1595]
MSEAPLPVAWTPTAKRALTRLPEKAAAAAVEFIYGPVAEIPRRVGKALRRELEGLYSARRGAFRIIYRISDVVTIMAIDH
RADTYRSH

Download         Length: 267 bp

>T197089 NZ_CP095540:3430811-3432133 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10231.65 Da        Isoelectric Point: 4.6983

>AT197089 WP_208091032.1 NZ_CP071870:c3360327-3360046 [Propioniciclava sp. MC1595]
MTVEGTMALRDVKNHLSEVVDQVEREHDRVVITKHGRPAAVVVSVDDLASLEETLDIAGRPQLMRQIRASLTEIAAGEAE
VVTKDEILRTLST

Download         Length: 282 bp

>AT197089 NZ_CP095540:3430545-3430811 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References