Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 77541..78114 Replicon chromosome
Accession NZ_CP071870
Organism Propioniciclava sp. MC1595

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J4N02_RS00360 Protein ID WP_188334836.1
Coordinates 77541..77891 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag J4N02_RS00365 Protein ID WP_220492351.1
Coordinates 77875..78114 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N02_RS00340 (J4N02_00340) 73245..74486 + 1242 WP_182818949.1 tyrosine-type recombinase/integrase -
J4N02_RS00345 (J4N02_00345) 74483..75457 + 975 WP_182818950.1 tyrosine-type recombinase/integrase -
J4N02_RS00350 (J4N02_00350) 75444..76463 + 1020 WP_182818952.1 tyrosine-type recombinase/integrase -
J4N02_RS00355 (J4N02_00355) 76544..77299 - 756 Protein_69 DDE-type integrase/transposase/recombinase -
J4N02_RS00360 (J4N02_00360) 77541..77891 - 351 WP_188334836.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J4N02_RS00365 (J4N02_00365) 77875..78114 - 240 WP_220492351.1 ribbon-helix-helix domain-containing protein Antitoxin
J4N02_RS00370 (J4N02_00370) 78279..78995 - 717 WP_129458362.1 hypothetical protein -
J4N02_RS00375 (J4N02_00375) 79180..79449 - 270 WP_223202774.1 hypothetical protein -
J4N02_RS00380 (J4N02_00380) 79455..79685 - 231 WP_208091050.1 hypothetical protein -
J4N02_RS00385 (J4N02_00385) 79844..80338 + 495 WP_182818908.1 hypothetical protein -
J4N02_RS00390 (J4N02_00390) 80566..81207 - 642 WP_188334717.1 response regulator transcription factor -
J4N02_RS00395 (J4N02_00395) 81204..82370 - 1167 WP_188334718.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-116)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12628.55 Da        Isoelectric Point: 8.6584

>T197085 WP_188334836.1 NZ_CP071870:c77891-77541 [Propioniciclava sp. MC1595]
MMLRGEIRLVDLEPARAGEADKRRPAVIVSNDNANATAARLGRGVVTVVPVTSNIARVYPFQVLLPADETGLHVDSKAQA
EQVRSVSVERIGPVTGRIPTYLLTQLDDALRLHLHL

Download         Length: 351 bp

>T197085 NZ_CP095540:2884554-2884805 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8423.22 Da        Isoelectric Point: 4.2257

>AT197085 WP_220492351.1 NZ_CP071870:c78114-77875 [Propioniciclava sp. MC1595]
MSQVKLSVSLSESEVAALDKYAHAAGLKSRSAAIQQAIRLLGDPELQSAYESAWREWEDSGNADAWDSAAADGMADAPR

Download         Length: 240 bp

>AT197085 NZ_CP095540:2884802-2885056 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References