Detailed information of TA system TA197083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 4063982..4064568
• Replicon: chromosome
• Accession: NZ_CP071868
• Organism: Pengzhenrongella sicca strain LRZ-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: J4E96_RS18655
• Protein ID: WP_227425835.1
• Coordinates: 4064224..4064568 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: J4E96_RS18650
• Protein ID: WP_227423521.1
• Coordinates: 4063982..4064230 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4E96_RS18645 (J4E96_18555)	4060488..4062914	-	2427	WP_227423520.1	SIR2 family protein	-
J4E96_RS18650 (J4E96_18560)	4063982..4064230	+	249	WP_227423521.1	CopG family transcriptional regulator	Antitoxin
J4E96_RS18655 (J4E96_18565)	4064224..4064568	+	345	WP_227425835.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
J4E96_RS18660 (J4E96_18570)	4064572..4065501	-	930	WP_227423522.1	DMT family transporter	-
J4E96_RS18665 (J4E96_18575)	4065618..4066187	+	570	WP_227423523.1	TetR/AcrR family transcriptional regulator	-
J4E96_RS18670 (J4E96_18580)	4066192..4067169	-	978	WP_227423524.1	HNH endonuclease signature motif containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12011.97 Da
• Isoelectric Point: 9.8916

>T197083 WP_227425835.1 NZ_CP071868:4064224-4064568 [Pengzhenrongella sicca]
MVIDRGGIYWANLGAPVGSRPAKRRPVVVISAQTYNQSRLATVVALVITSNTEMAAMPSNVFLPAAATGLPRDSVVNVTA
IVTLNKADLIEQAGLTPLALLRDIDRGLTSSLDL

Nucleotide

• Length: 345 bp

>T197083 NZ_CP095540:c1820998-1820621 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8896.75 Da
• Isoelectric Point: 4.2326

>AT197083 WP_227423521.1 NZ_CP071868:4063982-4064230 [Pengzhenrongella sicca]
MKTAISVPDDTFEKATRRAHDLGMSRSEFFTRAAARYLDELDAESVTRQIDLALAARPGADDAASDAVDVGHLILDDSSG
DW

Nucleotide

• Length: 249 bp

>AT197083 NZ_CP095540:c1821455-1821075 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG