Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1025196..1025712 Replicon chromosome
Accession NZ_CP071860
Organism Vibrio sp. SCSIO 43135

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4N42_RS19020 Protein ID WP_252031018.1
Coordinates 1025196..1025465 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U2ZH00
Locus tag J4N42_RS19025 Protein ID WP_005526636.1
Coordinates 1025458..1025712 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N42_RS19000 (J4N42_18965) 1021688..1022581 - 894 WP_252031007.1 LysR family transcriptional regulator -
J4N42_RS19005 (J4N42_18970) 1022854..1023039 + 186 WP_252031010.1 hypothetical protein -
J4N42_RS19010 (J4N42_18975) 1023122..1023781 - 660 WP_252031013.1 ATP-dependent zinc protease -
J4N42_RS19015 (J4N42_18980) 1023803..1024987 - 1185 WP_252031015.1 amino acid aminotransferase -
J4N42_RS19020 (J4N42_18985) 1025196..1025465 - 270 WP_252031018.1 Txe/YoeB family addiction module toxin Toxin
J4N42_RS19025 (J4N42_18990) 1025458..1025712 - 255 WP_005526636.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J4N42_RS19030 (J4N42_18995) 1025923..1027044 - 1122 WP_025523822.1 DUF4263 domain-containing protein -
J4N42_RS19035 (J4N42_19000) 1027092..1027184 - 93 WP_005433818.1 DUF3265 domain-containing protein -
J4N42_RS19040 (J4N42_19005) 1027199..1028425 - 1227 WP_252031021.1 HEPN domain-containing protein -
J4N42_RS19045 (J4N42_19010) 1028548..1029285 - 738 WP_252031024.1 hypothetical protein -
J4N42_RS19050 (J4N42_19015) 1029315..1029404 - 90 WP_252034218.1 DUF3265 domain-containing protein -
J4N42_RS19055 1029422..1029883 - 462 WP_252031027.1 hypothetical protein -
J4N42_RS22630 1030082..1030210 + 129 WP_286036679.1 hypothetical protein -
J4N42_RS19060 (J4N42_19025) 1030220..1030690 - 471 WP_252031029.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10526.89 Da        Isoelectric Point: 8.8578

>T197063 WP_252031018.1 NZ_CP071860:c1025465-1025196 [Vibrio sp. SCSIO 43135]
MSSSQRLLSWTDDAWGDYLYWQTQDKKALKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T197063 NZ_CP095538:2563492-2563599 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 5.0623

>AT197063 WP_005526636.1 NZ_CP071860:c1025712-1025458 [Vibrio sp. SCSIO 43135]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT197063 NZ_CP095538:c2563439-2563378 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A244CM06

References