Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1490255..1490771 | Replicon | chromosome |
| Accession | NZ_CP071857 | ||
| Organism | Vibrio sp. SCSIO 43145 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | J4N38_RS07225 | Protein ID | WP_252036458.1 |
| Coordinates | 1490502..1490771 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | J4N38_RS07220 | Protein ID | WP_252036457.1 |
| Coordinates | 1490255..1490509 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4N38_RS07185 (J4N38_07125) | 1485315..1485728 | + | 414 | WP_252036452.1 | hypothetical protein | - |
| J4N38_RS07190 (J4N38_07130) | 1485732..1487054 | - | 1323 | WP_252040103.1 | IS4 family transposase | - |
| J4N38_RS07195 (J4N38_07135) | 1487656..1487832 | + | 177 | WP_252036454.1 | hypothetical protein | - |
| J4N38_RS07200 (J4N38_07140) | 1487943..1488653 | + | 711 | WP_252036455.1 | hypothetical protein | - |
| J4N38_RS07205 (J4N38_07145) | 1488844..1489257 | + | 414 | WP_038162647.1 | RDD family protein | - |
| J4N38_RS07210 (J4N38_07150) | 1489276..1489368 | + | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| J4N38_RS07215 (J4N38_07155) | 1489410..1490036 | + | 627 | WP_252036456.1 | LysE family translocator | - |
| J4N38_RS07220 (J4N38_07160) | 1490255..1490509 | + | 255 | WP_252036457.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| J4N38_RS07225 (J4N38_07165) | 1490502..1490771 | + | 270 | WP_252036458.1 | Txe/YoeB family addiction module toxin | Toxin |
| J4N38_RS07230 (J4N38_07170) | 1490950..1491264 | + | 315 | WP_252036459.1 | hypothetical protein | - |
| J4N38_RS07235 (J4N38_07180) | 1491821..1491973 | + | 153 | WP_252036460.1 | hypothetical protein | - |
| J4N38_RS07240 (J4N38_07185) | 1491974..1492738 | + | 765 | WP_252036619.1 | PhzF family phenazine biosynthesis protein | - |
| J4N38_RS07245 (J4N38_07190) | 1492756..1492845 | + | 90 | WP_239871702.1 | DUF3265 domain-containing protein | - |
| J4N38_RS07250 (J4N38_07195) | 1492873..1493142 | + | 270 | WP_252036461.1 | hypothetical protein | - |
| J4N38_RS07255 (J4N38_07200) | 1493287..1493706 | + | 420 | WP_252036358.1 | hypothetical protein | - |
| J4N38_RS07260 (J4N38_07205) | 1493830..1494315 | + | 486 | WP_252036462.1 | GNAT family N-acetyltransferase | - |
| J4N38_RS07265 (J4N38_07210) | 1494487..1494783 | - | 297 | WP_252036463.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J4N38_RS07270 (J4N38_07215) | 1494790..1495032 | - | 243 | WP_005526987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1344026..1496374 | 152348 | |
| - | flank | IS/Tn | - | - | 1485732..1487054 | 1322 | |
| - | inside | Integron | - | - | 1343019..1495238 | 152219 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10600.93 Da Isoelectric Point: 7.9816
>T197061 WP_252036458.1 NZ_CP071857:1490502-1490771 [Vibrio sp. SCSIO 43145]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T197061 NZ_CP095538:2233455-2233733 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9483.63 Da Isoelectric Point: 5.0623
>AT197061 WP_252036457.1 NZ_CP071857:1490255-1490509 [Vibrio sp. SCSIO 43145]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTTRE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTTRE
LIDE
Download Length: 255 bp
>AT197061 NZ_CP095538:2233733-2234017 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|