Detailed information of TA system TA197060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1480739..1481284
• Replicon: chromosome
• Accession: NZ_CP071857
• Organism: Vibrio sp. SCSIO 43145

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J4N38_RS07145
• Protein ID: WP_252036446.1
• Coordinates: 1480739..1481035 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7X8YLC8
• Locus tag: J4N38_RS07150
• Protein ID: WP_005526987.1
• Coordinates: 1481042..1481284 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N38_RS07100 (J4N38_07045)	1475821..1476209	+	389	Protein_1372	lysozyme inhibitor LprI family protein	-
J4N38_RS07105 (J4N38_07050)	1476330..1476692	+	363	WP_252036441.1	hypothetical protein	-
J4N38_RS07110 (J4N38_07055)	1476937..1477305	+	369	WP_252036442.1	hypothetical protein	-
J4N38_RS07115 (J4N38_07060)	1477308..1477691	+	384	WP_252036443.1	hypothetical protein	-
J4N38_RS07120 (J4N38_07065)	1478154..1478303	+	150	WP_252036444.1	hypothetical protein	-
J4N38_RS07125 (J4N38_07070)	1479085..1479237	+	153	WP_252036460.1	hypothetical protein	-
J4N38_RS07130 (J4N38_07075)	1479238..1480002	+	765	WP_252036619.1	PhzF family phenazine biosynthesis protein	-
J4N38_RS07135 (J4N38_07080)	1480020..1480109	+	90	WP_239871702.1	DUF3265 domain-containing protein	-
J4N38_RS07140 (J4N38_07085)	1480156..1480563	+	408	WP_252036445.1	GFA family protein	-
J4N38_RS07145 (J4N38_07090)	1480739..1481035	-	297	WP_252036446.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J4N38_RS07150 (J4N38_07095)	1481042..1481284	-	243	WP_005526987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J4N38_RS07155 (J4N38_07100)	1482089..1482523	+	435	WP_252036447.1	hypothetical protein	-
J4N38_RS07160	1482550..1482642	+	93	WP_252036448.1	DUF3265 domain-containing protein	-
J4N38_RS07165 (J4N38_07105)	1482682..1483086	+	405	WP_252036449.1	GFA family protein	-
J4N38_RS07170 (J4N38_07110)	1483215..1483685	+	471	WP_252036393.1	hypothetical protein	-
J4N38_RS07175 (J4N38_07115)	1484316..1484612	+	297	WP_252036450.1	DUF6506 family protein	-
J4N38_RS07180 (J4N38_07120)	1484770..1485180	+	411	WP_252036451.1	hypothetical protein	-
J4N38_RS07185 (J4N38_07125)	1485315..1485728	+	414	WP_252036452.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1344026..1496374	152348
	-	flank	IS/Tn	-	-	1485732..1487054	1322
	-	inside	Integron	-	-	1343019..1495238	152219

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11253.88 Da
• Isoelectric Point: 9.6430

>T197060 WP_252036446.1 NZ_CP071857:c1481035-1480739 [Vibrio sp. SCSIO 43145]
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPAGKHTAYFTKEDC
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T197060 NZ_CP095538:2182829-2184151 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGCTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8974.16 Da
• Isoelectric Point: 4.7914

>AT197060 WP_005526987.1 NZ_CP071857:c1481284-1481042 [Vibrio sp. SCSIO 43145]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT197060 NZ_CP095538:2182563-2182829 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGTATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7X8YLC8